Featured Research

from universities, journals, and other organizations

Hormone replacement therapy cuts risk of repeat knee/hip replacement surgery by 40 percent

Date:
January 22, 2014
Source:
BMJ-British Medical Journal
Summary:
Hormone replacement therapy (HRT) taken regularly for six months after a knee or hip replacement seems to cut the risk of repeat surgery by around 40 percent, indicates a large population based study published.

Hormone replacement therapy (HRT) taken regularly for six months after a knee or hip replacement seems to cut the risk of repeat surgery by around 40%, indicates a large population based study published online in the Annals of the Rheumatic Diseases.

Related Articles


National data for England and Wales indicate that more than 2% of procedures typically have to be repeated within three years, primarily because of osteolysis (75% of cases).

Osteolysis occurs when particles from the implant seep into the surrounding tissue, prompting an inflammatory response which then destroys the bone around the implant.

And joint replacement surgery rates are set to rise substantially as the population ages and the prevalence of obesity increases, say the authors. The research team assessed the likelihood of repeat joint replacement surgery among women who required a first knee or hip replacement between 1986 and 2006.

The women's details had been entered into the primary care General Practice Research Database (GPRD), which holds millions of anonymized medical records for patients across the UK.

More than 21,000 eligible women who met the criteria had not used HRT, while more than 3500 had done so for at least six months, providing matched samples of 2700 HRT users and 8100 women who had not used HRT.

The risk of repeat surgery was tracked in both sets of women for a minimum of three years.

Those who had taken HRT regularly for six months or more after their surgery were 38% less likely to require repeat surgery than were those who had not done so.

Furthermore, those who regularly took HRT for 12 months or more after their procedure were more than 50% less likely to need further surgery during the three year monitoring period.

Taking HRT before surgery, however, made no difference to the risk of implant failure, the findings showed.

The findings held true even after taking account of other influential factors, including use of drugs that can impair bone turnover.

Low levels of the female hormone estrogen have been implicated in bone thinning and loss, while HRT is thought to help conserve bone thickness. But this is the first study to show that it can help prevent repeat surgery in women who have undergone hip/knee replacement, say the authors.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Prieto-Alhambra, M. K. Javaid, A. Judge, J. Maskell, C. Cooper, N. K. Arden, M. Mullee, J. Rafferty, A. Carr, A. Price, K. Javaid, D. Beard, D. Altman, N. Clarke. Hormone replacement therapy and mid-term implant survival following knee or hip arthroplasty for osteoarthritis: a population-based cohort study. Annals of the Rheumatic Diseases, 2014; DOI: 10.1136/annrheumdis-2013-204043

Cite This Page:

BMJ-British Medical Journal. "Hormone replacement therapy cuts risk of repeat knee/hip replacement surgery by 40 percent." ScienceDaily. ScienceDaily, 22 January 2014. <www.sciencedaily.com/releases/2014/01/140122202215.htm>.
BMJ-British Medical Journal. (2014, January 22). Hormone replacement therapy cuts risk of repeat knee/hip replacement surgery by 40 percent. ScienceDaily. Retrieved December 25, 2014 from www.sciencedaily.com/releases/2014/01/140122202215.htm
BMJ-British Medical Journal. "Hormone replacement therapy cuts risk of repeat knee/hip replacement surgery by 40 percent." ScienceDaily. www.sciencedaily.com/releases/2014/01/140122202215.htm (accessed December 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

French General Physicians Begin Strike, ER Doctors Back to Work

French General Physicians Begin Strike, ER Doctors Back to Work

AFP (Dec. 23, 2014) French doctors went on strike Tuesday in protest at an upcoming health bill. Emergency room doctors on the other end are returning to work after reaching an historic agreement. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
Malpractice Suit Changes Rule for Cruise Ships

Malpractice Suit Changes Rule for Cruise Ships

AP (Dec. 23, 2014) A recent court ruling may have opened the courthouse door for cruise ship passengers who claim poor treatment by ship medical personnel. (Dec. 23) Video provided by AP
Powered by NewsLook.com
Are Paper Books Better Than E-Books For Sleep Cycle?

Are Paper Books Better Than E-Books For Sleep Cycle?

Newsy (Dec. 23, 2014) A study from Harvard Medical School shows that electronic readers utilizing LED technology interrupt people's natural sleep cycles. Video provided by Newsy
Powered by NewsLook.com
Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins