Featured Research

from universities, journals, and other organizations

Study shows value of HRQOL assessment in small cell lung cancer

Date:
January 28, 2014
Source:
European Organisation for Research and Treatment of Cancer
Summary:
A new study found that health-related quality of life assessment in small-cell lung cancer randomized clinical trials provides relevant added information in studies where the treatment arms do not differ in terms of efficacy. It provides valuable information for those treatments where better health-related quality of life is associated with overall survival benefit. The study also found that even though the overall standard for reporting health-related quality of life was acceptable, there is still need for improvement regarding reporting in randomized clinical trials to optimize value.

An EORTC study published in the Lancet Oncology found that health-related quality of life (HRQOL) assessment in small-cell lung cancer randomized clinical trials provides relevant added information in studies where the treatment arms do not differ in terms of efficacy. More importantly, it provides valuable information for those treatments where better HRQOL is associated with overall survival benefit. The study also found that even though the overall standard for reporting health-related quality of life was acceptable, there is still need for improvement regarding its reporting in randomized clinical trials to optimize their value.

There were an estimated 410,000 new cases of lung cancer and 353,000 deaths in Europe in 2012. Small-cell lung cancer accounts for roughly 15% of all lung cancers, and most small-cell lung cancer patients present with advanced disease. Consequently, disease management and treatment focuses on symptom control and health-related quality of life. In randomized clinical trials, health-related quality of life of small-cell lung cancer is now being evaluated more frequently.

The objective of this EORTC study was to evaluate the adequacy of health-related quality of life methodology reporting in small-cell lung cancer randomized clinical trials and the possible impact of this on clinical decision making. The study concerned randomized clinical trials that implemented patient-reported health-related quality of life assessments and oncology treatments for adult small-cell lung cancer patients (18 years of age or older), were completed between January 1991 and December 2012, included 100 or more patients, and were published in English. Over 10,000 patients were classified as eligible for this study from 30 randomized clinical trials out of an initial pool of 79 studies found.

The EORTC study found that HRQOL was a secondary endpoint in 29 RCTs of which 53% reported no significant difference in overall survival (OS). A difference of HRQOL was reported in 77% of the positive-outcome trials, and in 50% of the negative-outcome trials. A priori hypothesis on the expected overall HRQOL outcome was defined in 27% of the RCTs. Baseline HRQOL assessment was stated as mandatory in 14% of the RCTs. Tests of statistical significance were applied in 90% of the RCTs and missing data were discussed in detail in 30% of the trials.

Dr. Andrew Bottomley, EORTC Assistant Director and an author of this study says, "The EORTC has been a leader in establishing standards for conducting systematic reviews of patient reported outcomes in oncology randomized clinical trials. Arguably, the most important point about science is if results are reproducible. We have seen, time and again in over a decade of systematic literature research, that our results are consistent. We hope our quality of life research program has been useful in obtaining robust clinical research results, that these can be interpreted with confidence, and that decision makers can accept these findings from clinical trials in oncology. We hope our research has led others to use the EORTC Patient Reported Outcomes Checklist to design and evaluate other clinical trials and ensure high quality HRQOL."


Story Source:

The above story is based on materials provided by European Organisation for Research and Treatment of Cancer. The original article was written by John Bean. Note: Materials may be edited for content and length.


Journal Reference:

  1. Efstathios Zikos, Irina Ghislain, Corneel Coens, Divine E Ediebah, Elizabeth Sloan, Chantal Quinten, Michael Koller, Jan P van Meerbeeck, Hans-Henning Flechtner, Roger Stupp, Athanasios Pallis, Agnes Czimbalmos, Mirjam A G Sprangers, Andrew Bottomley. Health-related quality of life in small-cell lung cancer: a systematic review on reporting of methods and clinical issues in randomised controlled trials. The Lancet Oncology, 2014; 15 (2): e78 DOI: 10.1016/S1470-2045(13)70493-5

Cite This Page:

European Organisation for Research and Treatment of Cancer. "Study shows value of HRQOL assessment in small cell lung cancer." ScienceDaily. ScienceDaily, 28 January 2014. <www.sciencedaily.com/releases/2014/01/140128113330.htm>.
European Organisation for Research and Treatment of Cancer. (2014, January 28). Study shows value of HRQOL assessment in small cell lung cancer. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/01/140128113330.htm
European Organisation for Research and Treatment of Cancer. "Study shows value of HRQOL assessment in small cell lung cancer." ScienceDaily. www.sciencedaily.com/releases/2014/01/140128113330.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins