Featured Research

from universities, journals, and other organizations

Immune drug helps patients with frequently replapsing kidney disease

Date:
January 30, 2014
Source:
American Society of Nephrology (ASN)
Summary:
A specific immune drug could help patients forgo toxic standard treatments that are often ineffective when dealing with frequently relapsing kidney disease.

In patients with a frequently-relapsing form of kidney disease, relapses decreased approximately five-fold for at least one year after patients took a single dose of rituximab, an antibody that targets the immune system and is often used to treat immune disorders such as lymphoma and arthritis. The findings, which will appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), suggest that this drug may provide considerable benefits for patients.

For most children and young adults with a kidney disorder called idiopathic nephrotic syndrome (INS), the disease is thought to arise from an abnormal immune response. Researchers have shown that the drug rituximab can help children with INS that responds to standard treatments consisting of steroids and immunosuppressants. Therefore, rituxmab may allow such patients to discontinue these potentially toxic medications, which can affect children's growth and can increase patients' risks for heart problems, infections, cancer, and other conditions.

But for children and adults whose disease does not respond as well to standard treatments -- and is categorized as being "frequently-relapsing" -- the benefits of rituximab are less clear.

To investigate, Piero Ruggenenti, MD and Giuseppe Remuzzi, MD, FRCP (Mario Negri Institute for Pharmacological Research, in Italy) led a team that evaluated rituximab therapy followed by immunosuppression withdrawal on disease recurrence in 10 children and 20 adults with IMN who had suffered two or more recurrences over the previous year. Patients received one or two doses of rituximab intravenously.

Among the major findings after one year: • All patients were in remission: 18 were treatment-free and 15 never relapsed. • Compared with the year before rituximab, total relapses decreased from 88 to 22 and per-patient median number of relapses decreased from 2.5 to 0.5. • After rituximab, per-patient steroid maintenance median dose decreased from 0.27 to 0 mg/kg, and median cumulative dose to achieve relapse remission decreased from 19.5 to 0.5 mg/kg. • Patients' kidney function increased, and rituximab was well tolerated.

The study reveals that rituximab can effectively and safely prevent recurrences and reduce the need for immunosuppression in frequently-relapsing INS.

"Finding that a relatively safe treatment like rituximab may prevent relapses of INS and avoid or reduce the need for steroids and other immunosuppressants may have major clinical implications since rituximab therapy might help limit the complications of both the disease and of concomitant treatments that are often devastating," said Dr. Remuzzi. "Importantly, the results were obtained with one single dose of rituximab, whereas previous protocols recommended the use of four and even more doses," he added.


Story Source:

The above story is based on materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Ruggenenti, B. Ruggiero, P. Cravedi, M. Vivarelli, L. Massella, M. Marasa, A. Chianca, N. Rubis, B. Ene-Iordache, M. Rudnicki, R. M. Pollastro, G. Capasso, A. Pisani, M. Pennesi, F. Emma, G. Remuzzi. Rituximab in Steroid-Dependent or Frequently Relapsing Idiopathic Nephrotic Syndrome. Journal of the American Society of Nephrology, 2014; DOI: 10.1681/ASN.2013030251

Cite This Page:

American Society of Nephrology (ASN). "Immune drug helps patients with frequently replapsing kidney disease." ScienceDaily. ScienceDaily, 30 January 2014. <www.sciencedaily.com/releases/2014/01/140130185335.htm>.
American Society of Nephrology (ASN). (2014, January 30). Immune drug helps patients with frequently replapsing kidney disease. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2014/01/140130185335.htm
American Society of Nephrology (ASN). "Immune drug helps patients with frequently replapsing kidney disease." ScienceDaily. www.sciencedaily.com/releases/2014/01/140130185335.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins