Featured Research

from universities, journals, and other organizations

Synthesized sponge chemical shows promise for cancer

Date:
February 7, 2014
Source:
RMIT University
Summary:
A promising compound for cancer treatment has been synthesized in a laboratory by a PhD student.

A promising compound for cancer treatment has been synthesized in a laboratory by an RMIT University researcher during his PhD research.

Dr Dan Balan, from the School of Applied Sciences at RMIT, said 15-aza-Salicylihalamide A analogue had demonstrated potent activity against several leukemia cell lines.

"Salicylihalamide A is an interesting natural marine product that has been isolated from a marine sponge of the genus Haliclona, collected from waters around Rottnest Island, 18 km off the coast of southern Western Australia," Dr Balan said.

Salicylihalamide A is cytotoxic -- or a toxin which is known to destroy cells and which also provides a defense for the sea sponge.

"My goal was to synthesise the chemical in the laboratory in the form of a single aza-salicylihalamide A analogue molecule," he said.

The aza-salicylihalamide A analogue molecules were then exposed to NCI-60 leukemia cell lines, and exhibited antiproliferating effects on the group of cells at highly diluted, or 'sub-molar', concentrations.

"15-aza-Salicylihalamide A Analogue has proven to be very active against various types of cancer, but it was clearly most active against HL-60, which is acute promyelocytic leukemia," he said.

Other findings revealed it to be an inhibitor of vacuolar ATPase and proton pumps, frequently found in metastatic cancer cells -- which are cancer cells that have migrated through the bloodstream from more advanced tumours.

"The molecule was synthesized in a short molecular sequence that could be easily produced in very large volumes for drug production," Dr Balan said.

He explained there will be further research to investigate its effectiveness on different cancers, potentially leading to extensive drug development.


Story Source:

The above story is based on materials provided by RMIT University. Note: Materials may be edited for content and length.


Cite This Page:

RMIT University. "Synthesized sponge chemical shows promise for cancer." ScienceDaily. ScienceDaily, 7 February 2014. <www.sciencedaily.com/releases/2014/02/140207083727.htm>.
RMIT University. (2014, February 7). Synthesized sponge chemical shows promise for cancer. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2014/02/140207083727.htm
RMIT University. "Synthesized sponge chemical shows promise for cancer." ScienceDaily. www.sciencedaily.com/releases/2014/02/140207083727.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins