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Special glasses help surgeons 'see' cancer​​​​​​​​

Date:
February 10, 2014
Source:
Washington University in St. Louis
Summary:
High-tech glasses may help surgeons visualize cancer cells, which glow blue when viewed through the eyewear. The wearable technology, so new it's yet unnamed, was used during surgery for the first time today at Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.

High-tech glasses developed at the School of Medicine help breast surgeon Julie Margenthaler, MD, visualize cancer cells in a patient Feb. 10. Inset: Still image from a video of the lymph node removal, as seen by Margenthaler as she wore the eyewear. A florescent marker injected into the patient and special lighting made cancer cells glow blue when viewed with the technology. The lighter the shade of blue, the more concentrated the cancer cells are.
Credit: Photo by Robert Boston / Image courtesy of Washington University School of Medicine

High-tech glasses developed at Washington University School of Medicine in St. Louis may help surgeons visualize cancer cells, which glow blue when viewed through the eyewear.

The wearable technology, so new it's yet unnamed, was used during surgery for the first time today at Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.

Cancer cells are notoriously difficult to see, even under high-powered magnification. The glasses are designed to make it easier for surgeons to distinguish cancer cells from healthy cells, helping to ensure that no stray tumor cells are left behind during surgery.

"We're in the early stages of this technology, and more development and testing will be done, but we're certainly encouraged by the potential benefits to patients," said breast surgeon Julie Margenthaler, MD, an associate professor of surgery at Washington University, who performed today's operation. "Imagine what it would mean if these glasses eliminated the need for follow-up surgery and the associated pain, inconvenience and anxiety."

Current standard of care requires surgeons to remove the tumor and some neighboring tissue that may or may not include cancer cells. The samples are sent to a pathology lab and viewed under a microscope. If cancer cells are found in neighboring tissue, a second surgery often is recommended to remove additional tissue that also is checked for the presence of cancer.

The glasses could reduce the need for additional surgical procedures and subsequent stress on patients, as well as time and expense.

Margenthaler said about 20 to 25 percent of breast cancer patients who have lumps removed require a second surgery because current technology doesn't adequately show the extent of the disease during the first operation.

"Our hope is that this new technology will reduce or ideally eliminate the need for a second surgery," she said.

The technology, developed by a team led by Samuel Achilefu, PhD, professor of radiology and biomedical engineering at Washington University, incorporates custom video technology, a head-mounted display and a targeted molecular agent that attaches to cancer cells, making them glow when viewed with the glasses.

In a study published in the Journal of Biomedical Optics, researchers noted that tumors as small as 1 mm in diameter (the thickness of about 10 sheets of paper) could be detected.

Ryan Fields, MD, a Washington University assistant professor of surgery and Siteman surgeon, plans to wear the glasses later this month when he operates to remove a melanoma from a patient. He said he welcomes the new technology, which theoretically could be used to visualize any type of cancer.

"A limitation of surgery is that it's not always clear to the naked eye the distinction between normal tissue and cancerous tissue," Fields said. "With the glasses developed by Dr. Achilefu, we can better identify the tissue that must be removed."

In pilot studies conducted on lab mice, the researchers utilized indocyanine green, a commonly used contrast agent approved by the Food and Drug Administration. When the agent is injected into the tumor, the cancerous cells glow when viewed with the glasses and a special light.

Achilefu, who also is co-leader of the Oncologic Imaging Program at Siteman Cancer Center and professor of biochemistry and molecular biophysics, is seeking FDA approval for a different molecular agent he's helping to develop for use with the glasses. This agent specifically targets and stays longer in cancer cells.

"This technology has great potential for patients and health-care professionals," Achilefu said. "Our goal is to make sure no cancer is left behind."

Dr. Achilefu has worked with Washington University's Office of Technology Management and has a patent pending for the technology.

The research is funded by the National Cancer Institute (R01CA171651) at the National Institutes of Health (NIH).


Story Source:

The above story is based on materials provided by Washington University in St. Louis. Note: Materials may be edited for content and length.


Cite This Page:

Washington University in St. Louis. "Special glasses help surgeons 'see' cancer​​​​​​​​." ScienceDaily. ScienceDaily, 10 February 2014. <www.sciencedaily.com/releases/2014/02/140210184257.htm>.
Washington University in St. Louis. (2014, February 10). Special glasses help surgeons 'see' cancer​​​​​​​​. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2014/02/140210184257.htm
Washington University in St. Louis. "Special glasses help surgeons 'see' cancer​​​​​​​​." ScienceDaily. www.sciencedaily.com/releases/2014/02/140210184257.htm (accessed April 18, 2014).

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