Featured Research

from universities, journals, and other organizations

Real time in-vivo molecular diagnostic system that diagnoses even pre-cancerous tissues during endoscopy: World's first

Date:
February 11, 2014
Source:
National University of Singapore
Summary:
An engineering team has pioneered the world’s first real time in-vivo molecular diagnostic system that diagnoses even pre-cancerous tissues during endoscopy.

Prof Ho (left) and Assoc Prof Huang demonstrating how their novel diagnostic system works at a media briefing.
Credit: Image courtesy of National University of Singapore

NUS Biomedical Engineering team pioneers world's first real time in-vivo molecular diagnostic system that diagnoses even pre-cancerous tissues during endoscopy

Related Articles


In-Vivo Molecular Diagnostic System developed by NUS team makes objective, real time cancer diagnosis during endoscopic examination a reality.

A National University of Singapore (NUS) team led by Associate Professor Huang Zhiwei, Department of Biomedical Engineering, has developed an In-Vivo Molecular Diagnostic System that could change the way cancer diagnosis is made.

Their diagnostic system is the only one in the world, so far, clinically proven to be used in human patients for diagnosing even pre-cancerous tissue in gastrointestinal tract during endoscopic examination in real time. Unlike conventional endoscopic techniques that relies on doctors' eyeball interpretation of the images followed by pathologists' analysis of the biopsy specimen several days later, their diagnostic system utilizes computer analysis of biomolecular information and therefore can provide objective diagnosis of cancer in real time. It is a paradigm shift in how a complex process of cancer diagnosis can be made simply, objectively, and rapidly.

The In-Vivo Molecular Diagnostic System, based on Confocal Raman spectroscopy, includes a proprietary confocal fiber-optic probe and customized online software control system designed by the NUS team. The fiber-optic probe enables the collection of biomolecular fingerprint of tissues in less than one second -- while the online software enables the biomolecular information collected to be extracted and analyzed with diagnostic result that is presented in real time during endoscopic examination.

The In-Vivo Molecular Diagnostic system has been used in more than 500 patients in Singapore across diverse cancer types like stomach, esophagus, colon, rectum, head and neck, and cervix. The researchers have also published more than 40 peer-reviewed publications -- their most recent publication being "Fiberoptic Confocal Raman Spectroscopy for Real Time In-Vivo Diagnosis of Dysplasia in Barret's Esophagus" (January 2014) in Gastroenterology. They have also filed two U.S. and two U.K. patents for their invention.

"We are delighted to not only overcome the technical challenges of weak Raman signal, high fiber background noise, and lack of depth perception by using our specially designed probe, but also to enable real time diagnostic results to be displayed during endoscopy with our customized software," said Assoc Prof Huang.

For the clinical testing, the NUS Engineering team has been collaborating with researchers from the NUS Yong Loo Lin School of Medicine led by the School's Dean, Associate Professor Yeoh Khay Guan; Professor Ho Khek Yu, Head, Department of Medicine; and Associate Professor Teh Ming, Head, Department of Pathology.

"It has been a long tedious journey of more than 10 years. The journey could be longer if not for the excellent cross-disciplinary teamwork at NUS. The contribution of the NUS clinical team is invaluable in demonstrating the clinical benefits of the system," added Assoc Prof Huang.

Assoc Prof Yeoh commented, "This remarkable new system is the first such diagnostic probe that can be used real time, inside the human body, providing almost instantaneous information on cellular changes including cancer and pre-cancer. This is a first in the world development, pioneered here in Singapore. It has the potential to make enormous clinical impact to how cancer is diagnosed and managed. The immediate point-of-care diagnosis during live endoscopic examinations will provide benefits in time and cost-savings, and will improve our patients' prognosis as a result of early diagnosis."

Moving forward, Assoc Prof Huang said they will be conducting clinical trials on a larger scale to further validate the clinical utility of their novel system especially in gastrointestinal cancers.

Real time and early diagnosis can reduce gastrointestinal cancer deaths

Gastrointestinal cancer as a class is very prevalent in Asia with stomach and colorectal cancer being the most common cancer types. It is also a very treatable cancer class when diagnosed early. Unfortunately mortality within gastrointestinal cancer is disproportionately high; gastrointestinal cancer is currently the second highest contributor to cancer deaths.

"We look forward to improving the prognosis of patients with gastrointestinal cancer by facilitating early cancer diagnosis with our In-Vivo Molecular Diagnostic System," he said.


Story Source:

The above story is based on materials provided by National University of Singapore. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mads Sylvest Bergholt, Wei Zheng, Khek Yu Ho, Ming Teh, Khay Guan Yeoh, Jimmy Bok Yan So, Asim Shabbir, Zhiwei Huang. Fiberoptic Confocal Raman Spectroscopy for Real-Time In Vivo Diagnosis of Dysplasia in Barrett's Esophagus. Gastroenterology, 2014; 146 (1): 27 DOI: 10.1053/j.gastro.2013.11.002

Cite This Page:

National University of Singapore. "Real time in-vivo molecular diagnostic system that diagnoses even pre-cancerous tissues during endoscopy: World's first." ScienceDaily. ScienceDaily, 11 February 2014. <www.sciencedaily.com/releases/2014/02/140211083808.htm>.
National University of Singapore. (2014, February 11). Real time in-vivo molecular diagnostic system that diagnoses even pre-cancerous tissues during endoscopy: World's first. ScienceDaily. Retrieved November 20, 2014 from www.sciencedaily.com/releases/2014/02/140211083808.htm
National University of Singapore. "Real time in-vivo molecular diagnostic system that diagnoses even pre-cancerous tissues during endoscopy: World's first." ScienceDaily. www.sciencedaily.com/releases/2014/02/140211083808.htm (accessed November 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN Says It Will Scale Up Its Ebola Response

UN Says It Will Scale Up Its Ebola Response

AFP (Nov. 20, 2014) UN Resident Coordinator David McLachlan-Karr and WHO representative in the country Daniel Kertesz updated the media on the UN Ebola response on Wednesday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com
Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Reuters - US Online Video (Nov. 20, 2014) U.S. Congress hears from a victim and company officials as it holds a hearing on the safety of Takata airbags after reports of injuries. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Obesity Costs Almost As Much As War And Terrorism

Obesity Costs Almost As Much As War And Terrorism

Newsy (Nov. 20, 2014) The newest estimate of the cost of obesity is pretty jarring — $2 trillion. But how did researchers get to that number? Video provided by Newsy
Powered by NewsLook.com
Calling All Men: Here's Your Chance to Experience Labor Pains

Calling All Men: Here's Your Chance to Experience Labor Pains

Reuters - Light News Video Online (Nov. 20, 2014) Chinese hospital offers men a chance to experience the pain of child birth via electric shocks. Sharon Reich reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins