Featured Research

from universities, journals, and other organizations

Alcohol-breakdown molecule may play a role in breast cancer development

Date:
February 11, 2014
Source:
Manchester University
Summary:
New research looking at the biological process involved in breast cancer development has strengthened the argument for a potential link between alcohol consumption and the disease.

New research looking at the biological process involved in breast cancer development has strengthened the argument for a potential link between alcohol consumption and the disease. Scientists from The University of Manchester -- part of the Manchester Cancer Research Centre -- and the University of Salford looked at a particular enzyme, a biological molecule that accelerates chemical reactions -- known as CYP2E1.

Their findings offer a possible target to improve outcomes for patients in the later stages of the disease.

Dr Costas Demonacos, based at The University's Manchester Pharmacy School who led the research, said: "This enzyme, known as CYP2E1, has been implicated in various liver diseases linked to alcohol consumption (Alcoholic Liver Disease (ALD), as well as diabetes, obesity and cancer.

"We wanted to understand why an enzyme known to function mainly in the liver was found to be heavily present in some types of breast cancer tissues. We also wanted to explore what other activities this enzyme might have that control the development of breast cancer."

The enzyme breaks down various molecules within cells, including alcohol. The by-products of this metabolism include reactive oxygen species (ROS), resulting in something called oxidative stress -- in normal physiological conditions this aids cellular functions, whereas when concentrations of ROS are high or oxidative stress becomes chronic, cells can be seriously damaged.

Previous studies have shown that the enzyme is most strongly expressed in early-stage breast tumours rather than more developed tumours and scientists believe that it contributes to the progression of breast cancer. The Manchester team looked at the role it plays in various cellular functions in breast cancer cells.

The study, published in Breast Cancer Research, found that depending on the stage of the breast cancer, high levels of the enzyme can help cells survive during stress.

They also found that inhibiting the activity of the enzyme in cells with high migratory potential promoted cell migration -- a process linked to cancer spreading -- known as metastasis.

Dr Demonacos said: "Now that we have a clearer picture of the role played by this enzyme in breast cancer development, scientists could use it as a target in the later stages of the disease, to slow down the spread of cancer as well as to personalise anti-cancer therapy.

"Since CYP2E1 is involved in alcohol metabolism too, our findings should allow new insight on the potential link between chronic alcohol consumption and breast cancer, by showing how alcohol influences the progression of cancer."


Story Source:

The above story is based on materials provided by Manchester University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Travis Leung, Ramkumar Rajendran, Subir Singh, Richa Garva, Marija Krstic-Demonacos, Constantinos Demonacos. Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. Breast Cancer Research, 2013; 15 (6): R107 DOI: 10.1186/bcr3574

Cite This Page:

Manchester University. "Alcohol-breakdown molecule may play a role in breast cancer development." ScienceDaily. ScienceDaily, 11 February 2014. <www.sciencedaily.com/releases/2014/02/140211083901.htm>.
Manchester University. (2014, February 11). Alcohol-breakdown molecule may play a role in breast cancer development. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2014/02/140211083901.htm
Manchester University. "Alcohol-breakdown molecule may play a role in breast cancer development." ScienceDaily. www.sciencedaily.com/releases/2014/02/140211083901.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins