Featured Research

from universities, journals, and other organizations

Metal implants may cut chemotherapy side effects, study suggests

Date:
February 13, 2014
Source:
University of Edinburgh
Summary:
Cancer patients could one day experience fewer side effects from chemotherapy following a discovery that opens the door for more targeted treatments. Researchers have identified a possible way of treating tumors that would see doctors place harmless metal implants at the cancer site.

Scientists have developed modified chemotherapy drugs that are designed to remain inactive until they come into contact with a palladium implant located at the tumor site. The hope is that this approach could help to reduce the side effects associated with treatment by minimizing damage to the rest of the body.
Credit: Asier Unciti-Broceta

Cancer patients could one day experience fewer side effects from chemotherapy following a discovery that opens the door for more targeted treatments.

Researchers have identified a possible way of treating tumors that would see doctors place harmless metal implants at the cancer site.

The discovery could make treatment more targeted than existing therapies, avoiding unwanted side effects, such as hair loss, tiredness and nausea. These occur when chemotherapy drugs carried in the blood kill healthy cells as well as cancer cells.

The scientists found that they could alter the chemical composition of commonly used chemotherapy drugs so that they only become active when they come into contact with a metal called palladium.

Researchers hope that by implanting small devices coated with palladium into patients' tumors, the drugs would become activated only where they are needed, causing minimal damage to the rest of the body.

The scientists reported their discovery today in the journal Nature Communications but the approach will first need to be tested in animals before it can be studied in patients.

The research was led by scientists from the Edinburgh Cancer Research UK Centre at the MRC Institute of Genetics and Molecular Medicine, the University of Edinburgh.

Dr Asier Unciti-Broceta, who led the study, said: "It will be several years before we're able to start treating patients but we're hopeful that this approach will lead to better tolerated cancer therapies in the future."


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jason T. Weiss, John C. Dawson, Kenneth G. Macleod, Witold Rybski, Craig Fraser, Carmen Torres-Sαnchez, E. Elizabeth Patton, Mark Bradley, Neil O. Carragher, Asier Unciti-Broceta. Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach. Nature Communications, 2014; 5 DOI: 10.1038/ncomms4277

Cite This Page:

University of Edinburgh. "Metal implants may cut chemotherapy side effects, study suggests." ScienceDaily. ScienceDaily, 13 February 2014. <www.sciencedaily.com/releases/2014/02/140213094339.htm>.
University of Edinburgh. (2014, February 13). Metal implants may cut chemotherapy side effects, study suggests. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2014/02/140213094339.htm
University of Edinburgh. "Metal implants may cut chemotherapy side effects, study suggests." ScienceDaily. www.sciencedaily.com/releases/2014/02/140213094339.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins