Featured Research

from universities, journals, and other organizations

Limiting Radiation to Major Salivary Glands in Head, Neck Cancer Patients Is Feasible, Safe

Date:
February 20, 2014
Source:
American Society for Radiation Oncology (ASTRO)
Summary:
Avoiding the contralateral submandibular gland during radiation therapy is feasible and safe with advanced stage, node positive head and neck cancers and base of tongue lesions, according to research. While this seems worrisome because head and neck cancer spreads through the lymph nodes, it is well established that the risk of cancer involvement in the lymph nodes near the submandibular gland is exceedingly low, yet the benefit of sparing the gland for a patient's quality of life is high.

Avoiding the contralateral submandibular gland during radiation therapy is feasible and safe with advanced stage, node positive head and neck cancers and base of tongue lesions, according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium.

Researchers conducted a retrospective analysis of 71 patients from two facilities -- the University of Colorado Cancer Center and the Memorial Sloan-Kettering Cancer Center. The median patient age was 55, and about 50 percent of the patients were current or former smokers. Forty patients had primary tonsil cancers, and 31 patients had tumors involving the base of the tongue. About 80 percent of patients had N2b or greater disease (meaning extensive lymph node involvement), and 90 percent of patients had overall stage IV disease (indicating advanced cancer). The analysis only included patients who were receiving treatment to the bilateral neck.

All of the patients had been treated with radiation techniques that spared the contralateral submandibular gland (cSMG), which indicates it was on the opposite side of the neck as the cancer. Submandibular glands are major salivary glands located beneath the floor of the mouth and are responsible for the majority of unstimulated salivary flow. The mean dose to the cSMG was 33.04 Gy, and at a median follow-up of 27.3 months, no patients had experienced recurrences in the contralateral level Ib lymph nodes (the area of the spared submandibular gland).

"Sparing the submandibular gland from radiation can decrease the side effect of dry mouth, which has a substantial impact on patients' quality of life," said Tyler Robin, PhD, lead author of the study and an MD candidate in his final year at the University of Colorado School of Medicine. "Historically, however, there has been hesitation to spare the submandibular gland from radiation because there are lymph nodes near the gland that also end up not getting treated.

While this seems worrisome because head and neck cancer spreads through the lymph nodes, it is well established that the risk of cancer involvement in the lymph nodes near the submandibular gland is exceedingly low, yet the benefit of sparing the gland for a patient's quality of life is high. It is important to consider treatment side effects alongside treatment benefit, and overall, our goal is to decrease side effects associated with radiation treatment without undertreating a patient's cancer. With modern advances in radiation therapy, it is possible to eloquently treat cancers while avoiding surrounding normal tissues. Our study is a prime example of how we can safely spare normal tissue in appropriate patients in order to decrease treatment side effects."


Story Source:

The above story is based on materials provided by American Society for Radiation Oncology (ASTRO). Note: Materials may be edited for content and length.


Cite This Page:

American Society for Radiation Oncology (ASTRO). "Limiting Radiation to Major Salivary Glands in Head, Neck Cancer Patients Is Feasible, Safe." ScienceDaily. ScienceDaily, 20 February 2014. <www.sciencedaily.com/releases/2014/02/140220102606.htm>.
American Society for Radiation Oncology (ASTRO). (2014, February 20). Limiting Radiation to Major Salivary Glands in Head, Neck Cancer Patients Is Feasible, Safe. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2014/02/140220102606.htm
American Society for Radiation Oncology (ASTRO). "Limiting Radiation to Major Salivary Glands in Head, Neck Cancer Patients Is Feasible, Safe." ScienceDaily. www.sciencedaily.com/releases/2014/02/140220102606.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins