Featured Research

from universities, journals, and other organizations

Cell behavior mapped in low oxygen conditions, may lead to cancer treatment

Date:
February 20, 2014
Source:
University of Liverpool
Summary:
Research has explained how cells behave when placed in a low oxygen environment, a development that could have implications for cancer patients and other serious illnesses. The findings open up the possibility of controlling the signals that keep cells alive, preventing the damages caused by ischemia -- a restriction of blood supply to tissues. It could also work to help destroy cancer cells.

Research at the University of Liverpool has explained how cells behave when placed in a low oxygen environment, a development that could have implications for cancer patients and other serious illnesses.

Related Articles


The research opens up the possibility of controlling the signals that keep cells alive, preventing the damages caused by ischemia -- a restriction of blood supply to tissues. It could also work to help destroy cancer cells.

When the body is deprived of adequate oxygen supply it is known as hypoxia and can cause the death of cells. This occurs in patients suffering from 'ischemia', which can lead to gangrene or paralysis.

A reduction in oxygen levels, such as that used in the new study and which mimics the situation in a tumor, causes cells to adapt to the new environment and become resistant.

The researchers from the Institute of Integrative Biology in collaboration with researchers from the Department of Mathematical Sciences at the University, subjected cells to conditions with only 1% oxygen for 20 hours, and imaged the cellular response in real-time. They then mathematically modelled the profile of the proteins which conveyed instructions telling the cells how to behave.

It has not been established before why some cells died and others lived under low oxygen conditions, but by monitoring the levels of proteins in the cells and observing how they influenced genes switching on in the cells, the researchers were able to determine the optimum conditions for keeping cells alive.

Cell biologist, Dr Violaine See, who led the project, said: "These findings could have important consequences for how we understand tumors, which are hypoxic because of the rapid cell growth which outpaces their blood supply."

The study was published in the Journal of Biological Chemistry


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Bagnall, J. Leedale, S. Taylor, D. G. Spiller, M. R. H. White, K. J. Sharkey, R. N. Bearon, V. See. Tight control of Hypoxia Inducible Factor (HIF)-alpha transient dynamics is essential for cell survival in hypoxia. Journal of Biological Chemistry, 2014; DOI: 10.1074/jbc.M113.500405

Cite This Page:

University of Liverpool. "Cell behavior mapped in low oxygen conditions, may lead to cancer treatment." ScienceDaily. ScienceDaily, 20 February 2014. <www.sciencedaily.com/releases/2014/02/140220102919.htm>.
University of Liverpool. (2014, February 20). Cell behavior mapped in low oxygen conditions, may lead to cancer treatment. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2014/02/140220102919.htm
University of Liverpool. "Cell behavior mapped in low oxygen conditions, may lead to cancer treatment." ScienceDaily. www.sciencedaily.com/releases/2014/02/140220102919.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins