Featured Research

from universities, journals, and other organizations

Cell behavior mapped in low oxygen conditions, may lead to cancer treatment

Date:
February 20, 2014
Source:
University of Liverpool
Summary:
Research has explained how cells behave when placed in a low oxygen environment, a development that could have implications for cancer patients and other serious illnesses. The findings open up the possibility of controlling the signals that keep cells alive, preventing the damages caused by ischemia -- a restriction of blood supply to tissues. It could also work to help destroy cancer cells.

Research at the University of Liverpool has explained how cells behave when placed in a low oxygen environment, a development that could have implications for cancer patients and other serious illnesses.

The research opens up the possibility of controlling the signals that keep cells alive, preventing the damages caused by ischemia -- a restriction of blood supply to tissues. It could also work to help destroy cancer cells.

When the body is deprived of adequate oxygen supply it is known as hypoxia and can cause the death of cells. This occurs in patients suffering from 'ischemia', which can lead to gangrene or paralysis.

A reduction in oxygen levels, such as that used in the new study and which mimics the situation in a tumor, causes cells to adapt to the new environment and become resistant.

The researchers from the Institute of Integrative Biology in collaboration with researchers from the Department of Mathematical Sciences at the University, subjected cells to conditions with only 1% oxygen for 20 hours, and imaged the cellular response in real-time. They then mathematically modelled the profile of the proteins which conveyed instructions telling the cells how to behave.

It has not been established before why some cells died and others lived under low oxygen conditions, but by monitoring the levels of proteins in the cells and observing how they influenced genes switching on in the cells, the researchers were able to determine the optimum conditions for keeping cells alive.

Cell biologist, Dr Violaine See, who led the project, said: "These findings could have important consequences for how we understand tumors, which are hypoxic because of the rapid cell growth which outpaces their blood supply."

The study was published in the Journal of Biological Chemistry


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Bagnall, J. Leedale, S. Taylor, D. G. Spiller, M. R. H. White, K. J. Sharkey, R. N. Bearon, V. See. Tight control of Hypoxia Inducible Factor (HIF)-alpha transient dynamics is essential for cell survival in hypoxia. Journal of Biological Chemistry, 2014; DOI: 10.1074/jbc.M113.500405

Cite This Page:

University of Liverpool. "Cell behavior mapped in low oxygen conditions, may lead to cancer treatment." ScienceDaily. ScienceDaily, 20 February 2014. <www.sciencedaily.com/releases/2014/02/140220102919.htm>.
University of Liverpool. (2014, February 20). Cell behavior mapped in low oxygen conditions, may lead to cancer treatment. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2014/02/140220102919.htm
University of Liverpool. "Cell behavior mapped in low oxygen conditions, may lead to cancer treatment." ScienceDaily. www.sciencedaily.com/releases/2014/02/140220102919.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins