Featured Research

from universities, journals, and other organizations

Simple urine test detects common causes of kidney dysfunction after transplantation

Date:
March 6, 2014
Source:
American Society of Nephrology (ASN)
Summary:
A new urine test can distinguish among different causes of kidney dysfunction in kidney transplant recipients. Still under development, if it is validated in a larger multicenter study, the test may allow patients to avoid invasive kidney biopsies. "Our study shows that when the creatinine level is elevated in the blood of a kidney transplant recipient, use of our urine test would differentiate the common causes of kidney dysfunction that led to the elevation in creatinine, hence benefiting many patients by allowing them to avoid the need for an invasive needle biopsy," said the lead researcher.

A new noninvasive urine test can distinguish among different causes of acute kidney dysfunction after transplantation. The test, which is described in a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN), may allow patients to avoid invasive kidney biopsies when their transplanted organ is not functioning properly.

When creatinine levels are elevated in the blood of a kidney transplant recipient, it is an indication that the transplanted kidney is not functioning well. There are several reasons for transplant kidney dysfunction, and none of the blood or urine tests can reliably differentiate them. Because it is important to establish the exact reason for kidney dysfunction in order to determine the appropriate treatment, physicians typically perform a needle biopsy of the transplanted kidney.

Now, however, Thangamani Muthukumar, MD (Weill Medical College of Cornell University) and his colleagues have developed a urine test that measures the levels of several messenger RNAs (mRNAs) that are directly related to the disease processes that cause kidney dysfunction. The researchers measured absolute levels of mRNAs in 84 urine samples from 84 kidney transplant recipients who had undergone needle biopsy of the transplanted kidney to determine the cause of their acute kidney dysfunction.

"Using statistical methods we have combined the mRNAs to yield a diagnostic signature," explained Dr. Muthukumar. The researchers developed two such signatures from cells found in the urine that could differentiate, in a two-step approach, the common causes of acute kidney dysfunction with high accuracy.

"Our study shows that when the creatinine level is elevated in the blood of a kidney transplant recipient, use of our urine test would differentiate the common causes of kidney dysfunction that led to the elevation in creatinine, hence benefiting many patients by allowing them to avoid the need for an invasive needle biopsy," said Dr. Muthukumar.


Story Source:

The above story is based on materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Journal Reference:

  1. Marie Matignon, Ruchuang Ding, Darshana M. Dadhania, Franco B. Mueller, Choli Hartono, Catherine Snopkowski, Carol Li, John R. Lee, Daniel Sjoberg, Surya V. Seshan, Vijay K. Sharma, Hua Yang, Bakr Nour, Andrew J. Vickers, Manikkam Suthanthiran, and Thangamani Muthukumar. Urinary Cell mRNA Profiles and Differential Diagnosis of Acute Kidney Graft Dysfunction. Journal of the American Society of Nephrology, March 2014 DOI: 10.1681/ASN.2013080900

Cite This Page:

American Society of Nephrology (ASN). "Simple urine test detects common causes of kidney dysfunction after transplantation." ScienceDaily. ScienceDaily, 6 March 2014. <www.sciencedaily.com/releases/2014/03/140306191402.htm>.
American Society of Nephrology (ASN). (2014, March 6). Simple urine test detects common causes of kidney dysfunction after transplantation. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/03/140306191402.htm
American Society of Nephrology (ASN). "Simple urine test detects common causes of kidney dysfunction after transplantation." ScienceDaily. www.sciencedaily.com/releases/2014/03/140306191402.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins