Featured Research

from universities, journals, and other organizations

Discrepancies in clinical trial reporting raise questions of accuracy

Date:
March 12, 2014
Source:
Yale University
Summary:
In an analysis of 96 research trial results published in top journals, almost all had at least one discrepancy between what was reported on the public clinical trial registry clinicaltrials.gov and what was posted in the journal article. A new research letter raises serious questions about the accuracy of results reporting in both clinical trial registries and publications, and the importance of consistent presentation of accurate results.

In a Yale School of Medicine analysis of 96 research trial results published in top journals, almost all had at least one discrepancy between what was reported on the public clinical trial registry clinicaltrials.gov and what was posted in the journal article.

Related Articles


"This study raises serious questions about the accuracy of results reporting in both clinical trial registries and publications, and the importance of consistent presentation of accurate results," said Joseph Ross, M.D., assistant professor of medicine and public health at Yale School of Medicine and senior author of the research letter published in the March 12 Journal of the American Medical Association.

In 2007, the Food and Drug Administration mandated that all clinical trial results must be registered within one year of completion through clinicaltrials.gov, a National Institutes of Health online registry and database of clinical trials.

Ross and his colleagues compared the results of 96 trials reported through clinicaltrials.gov and those published in high-profile, peer-reviewed journals between 2010 and 2011. They compared the reported and published results regarding the patients, trial interventions, efficacy, and other results of the studies.

Of the 96 trials examined in this study, 93 of them had at least one discrepancy between the two reported results. "We focused only on reports in top journals such as the New England Journal of Medicine and Lancet, which tend to go through the most scrutiny before being published," explained Ross. "We believe that the results from this study represent the best-case scenario with respect to reporting accuracy in published clinical trials."

According to the analysis, discrepancies found between the clinicaltrials.gov database and published results could result from clerical or typographical errors, failure to report results online, or intentional changes to share more favorable results.

"Fortunately, of the 96 trials studied, only six of the discordant results altered the interpretation of the trial," said Ross. "But there still needs to be greater efforts to ensure accurate reporting in the future."


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jessica E. Becker, Harlan M. Krumholz, Gal Ben-Josef, Joseph S. Ross. Reporting of Results in ClinicalTrials.gov and High-Impact Journals. JAMA, 2014; 311 (10): 1063 DOI: 10.1001/jama.2013.285634

Cite This Page:

Yale University. "Discrepancies in clinical trial reporting raise questions of accuracy." ScienceDaily. ScienceDaily, 12 March 2014. <www.sciencedaily.com/releases/2014/03/140312103500.htm>.
Yale University. (2014, March 12). Discrepancies in clinical trial reporting raise questions of accuracy. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2014/03/140312103500.htm
Yale University. "Discrepancies in clinical trial reporting raise questions of accuracy." ScienceDaily. www.sciencedaily.com/releases/2014/03/140312103500.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Science & Society News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

After Sony Hack, What's Next?

After Sony Hack, What's Next?

Reuters - US Online Video (Dec. 19, 2014) The hacking attack on Sony Pictures has U.S. government officials weighing their response to the cyber-attack. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Navy Unveils Robot Fish

Navy Unveils Robot Fish

Reuters - Light News Video Online (Dec. 18, 2014) The U.S. Navy unveils an underwater device that mimics the movement of a fish. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
How 2014 Shaped The Future Of The Internet

How 2014 Shaped The Future Of The Internet

Newsy (Dec. 18, 2014) It has been a long, busy year for Net Neutrality. The stage is set for an expected landmark FCC decision sometime in 2015. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Science & Society

Business & Industry

Education & Learning

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins