Featured Research

from universities, journals, and other organizations

Stopping malaria transmission: Biochemist out for blood

Date:
March 19, 2014
Source:
Virginia Tech (Virginia Polytechnic Institute and State University)
Summary:
Researchers are examining the crucial time when malaria is transmitted from a mosquito parasite to humans. The effort will attempt to identify new drug targets to prevent malaria, and specifically the role that specific metabolites called isoprenoids play in the early stages of development.

Fighting malaria in today's world will require a new, targeted approach, and Virginia Tech researchers are out for blood.

Related Articles


The parasites responsible for the mosquito-borne infectious disease are increasingly resistant to current drug approaches, and almost half of the world is at risk of contracting an illness.

Maria Belen Cassera, an assistant professor of biochemistry in the College of Agriculture and Life Sciences, and a Fralin Life Science Institute affiliate, examines the metabolism of the malaria-causing parasite Plasmodium falciparum in order to identify new drug targets.

Her newest project, funded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, will look at the crucial time when malaria is transmitted -- when reproductive cell precursors known as gametocytes develop.

Specifically, she wants to understand the role that specific metabolites called isoprenoids play in the early stages of development.

"We think that understanding the role of isoprenoids during gametocytogenesis and identifying metabolic steps absent or sufficiently different from its human host will allow us to design more efficient drugs to block malaria transmission, which is one of the key components for malaria elimination and eradication," Cassera said.

The metabolic pathways that the parasite uses are not found in humans, so pathway-specific drugs would have little effect on the human host.

"Dr. Cassera has taken a leap forward in malaria research by identifying a unique pathway at an essential step in parasite development and transmission to mosquitoes," said Vern Schramm, the Ruth Merns Chair and Professor of Biochemistry at the Albert Einstein College of Medicine, and former postdoctoral mentor to Cassera. "Dr. Cassera is one of a select few scientists who can work productively at the level of parasite biochemistry, biology, drug discovery, transmission, and even primate models of the disease. Her talents have been justly recognized by support from the NIH."


Story Source:

The above story is based on materials provided by Virginia Tech (Virginia Polytechnic Institute and State University). Note: Materials may be edited for content and length.


Cite This Page:

Virginia Tech (Virginia Polytechnic Institute and State University). "Stopping malaria transmission: Biochemist out for blood." ScienceDaily. ScienceDaily, 19 March 2014. <www.sciencedaily.com/releases/2014/03/140319164903.htm>.
Virginia Tech (Virginia Polytechnic Institute and State University). (2014, March 19). Stopping malaria transmission: Biochemist out for blood. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2014/03/140319164903.htm
Virginia Tech (Virginia Polytechnic Institute and State University). "Stopping malaria transmission: Biochemist out for blood." ScienceDaily. www.sciencedaily.com/releases/2014/03/140319164903.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins