Featured Research

from universities, journals, and other organizations

New drug therapy for CLL under examination

Date:
March 19, 2014
Source:
North Shore-Long Island Jewish (LIJ) Health System
Summary:
Two American physicians weigh in on a German study of a new drug therapy for CLL. CLL is one of the most common forms of blood cancers, usually affecting those later in life. In the editorial, they point out that an important factor in the study is that most of the nearly 800 subjects are elderly with coexisting other health issues.

Two North Shore-LIJ Cancer Institute doctors, world-renowned for their research in chronic lymphocytic leukemia (CLL), weigh in on a German study of a new drug therapy for CLL in the March 20 edition of the New England Journal of Medicine, the North Shore-LIJ Health System announced today.

Related Articles


CLL is one of the most common forms of blood cancers, usually affecting those later in life. In an editorial written by Kanti Rai, MD, chief of CLL Research and Treatment Program for the health system, and Jacqueline Barrientos, MD, a research hematologist on staff at the CLL Program, they point out that an important factor in the study is that most of the nearly 800 subjects are elderly with coexisting other health issues.

Until now, researchers have skipped this population in favor of younger and healthier subjects, say the doctors, who also have academic appointments at Hofstra North Shore-LIJ School of Medicine. However, the average age of CLL patients at diagnosis is 72, and most usually have other health problems.

The study focused on the use of obinutuzumab, an antibody that binds to the protein CD20, in subjects with previously untreated CLL and coexisting conditions. Most cases of CLL start in white blood cells that have CD20 on their surface.

Researchers compared the benefits of obinutuzumab with that of another antibody rituximab, which also attacks CD20. Both drugs were combined with the chemotherapy drug chlorambucil. They found that subjects receiving obinutuzumab-chlorambucil had an average of 26.7 months progression-free of the disorder compared to 16.3 for those given rituximab-chlorambucil. To read more about the study, visit the New England Journal of Medicine online.

Findings of the study will have an important impact on future CLL research, explained Dr. Rai, who is also an investigator at North Shore-LIJ's Feinstein Institute for Medical Research. "The researchers' work will encourage future use of obinutuzumab in combination with other drugs and help shape the clinical landscape of CLL in the next decade."


Story Source:

The above story is based on materials provided by North Shore-Long Island Jewish (LIJ) Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kanti R. Rai, Jacqueline C. Barrientos. Movement toward Optimization of CLL Therapy. New England Journal of Medicine, 2014; 370 (12): 1160 DOI: 10.1056/NEJMe1400599

Cite This Page:

North Shore-Long Island Jewish (LIJ) Health System. "New drug therapy for CLL under examination." ScienceDaily. ScienceDaily, 19 March 2014. <www.sciencedaily.com/releases/2014/03/140319195857.htm>.
North Shore-Long Island Jewish (LIJ) Health System. (2014, March 19). New drug therapy for CLL under examination. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2014/03/140319195857.htm
North Shore-Long Island Jewish (LIJ) Health System. "New drug therapy for CLL under examination." ScienceDaily. www.sciencedaily.com/releases/2014/03/140319195857.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins