Featured Research

from universities, journals, and other organizations

Novel biomarker for head and neck cancer, non-small cell lung cancer identified

Date:
April 2, 2014
Source:
The Scripps Research Institute
Summary:
A new biomarker linked to better outcomes of patients with head and neck cancers and non-small cell lung cancer has been identified by researchers. The work could help scientists develop new diagnostics and therapies and help physicians determine the best long-term treatments for patients with these cancers.

A team led by a scientist from the Florida campus of The Scripps Research Institute (TSRI) has identified a new biomarker linked to better outcomes of patients with head and neck cancers and non-small cell lung cancer. The work could help scientists develop new diagnostics and therapies and help physicians determine the best long-term treatments for patients with these cancers.

The findings, which were published this week online ahead of print by the journal Cancer, focus on a protein called Choline phosphate cytidylyltransferase-α CCT-α or CCTα, an “antigen” that prompts the immune system to produce antibodies against it.

“Based on what we found, a high CCTα expression appears to be indicative of survival, making CCTα a promising biomarker,” said Laura Niedernhofer, a TSRI associate professor who led the study with Gerold Bepler of the Karmanos Cancer Institute. “Our findings suggest that CCTα may, in fact, be more important in determining outcomes in patients with both types of cancer than the already established ERCC1.”

The new study, in fact, turns previous studies on ERCC1 on their heads. Dozens of large clinical trials are being conducted using expression of the ERCC1 DNA-repair protein as a determinant of whether patients with lung, pancreatic, gastric, colorectal, esophageal or ovarian cancer should be treated with platinum-based therapy, a very potent but toxic DNA-damaging agent.

However, the new research suggests that these positive results were not actually due to ERCC1, but to CCTα—which also binds to the antibody most frequently used to measure ERCC1 expression. “Our results show CCTα may be a better predictor of patient outcomes than expression of ERCC1,” said Niedernhofer.

While ERCC1 is associated with DNA repair, CCTα is involved in the synthesis of a major component of cell membranes, active in membrane-mediated signaling and embryo survival.

The new results were based on an examination of samples from 187 patients with non-small cell lung cancer and 60 patients with head and neck squamous cell carcinomas.

CCTα expression was associated with longer survival rates, including for patients with non-small cell lung cancer who were treated with surgery alone—without the use of platinum-based chemotherapy drugs and associated toxic side effects.


Story Source:

The above story is based on materials provided by The Scripps Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alec E. Vaezi, Gerold Bepler, Nikhil R. Bhagwat, Agnes Malysa, Jennifer M. Rubatt, Wei Chen, Brian L. Hood, Thomas P. Conrads, Lin Wang, Carolyn E. Kemp, Laura J. Niedernhofer. Choline phosphate cytidylyltransferase-α is a novel antigen detected by the anti-ERCC1 antibody 8F1 with biomarker value in patients with lung and head and neck squamous cell carcinomas. Cancer, 2013; DOI: 10.1002/cncr.28643

Cite This Page:

The Scripps Research Institute. "Novel biomarker for head and neck cancer, non-small cell lung cancer identified." ScienceDaily. ScienceDaily, 2 April 2014. <www.sciencedaily.com/releases/2014/04/140402140342.htm>.
The Scripps Research Institute. (2014, April 2). Novel biomarker for head and neck cancer, non-small cell lung cancer identified. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2014/04/140402140342.htm
The Scripps Research Institute. "Novel biomarker for head and neck cancer, non-small cell lung cancer identified." ScienceDaily. www.sciencedaily.com/releases/2014/04/140402140342.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins