Featured Research

from universities, journals, and other organizations

Living organ regenerated for first time: Thymus rebuilt in mice

Date:
April 8, 2014
Source:
University of Edinburgh
Summary:
Scientists have succeeded in regenerating a living organ for the first time. Researchers rebuilt the thymus -- an organ in the body located next to the heart that produces important immune cells. The advance could pave the way for new therapies for people with damaged immune systems and genetic conditions that affect thymus development. The team reactivated a natural mechanism that shuts down with age to rejuvenate the thymus in very old mice. After treatment, the regenerated organ had a similar structure to that found in a young mouse.

Lab mouse (stock image).
Credit: mgkuijpers / Fotolia

A team of scientists at the University of Edinburgh has succeeded in regenerating a living organ for the first time.

Related Articles


The team rebuilt the thymus -- an organ in the body located next to the heart that produces important immune cells.

Immune repair

The advance could pave the way for new therapies for people with damaged immune systems and genetic conditions that affect thymus development.

The team reactivated a natural mechanism that shuts down with age to rejuvenate the thymus in very old mice. After treatment, the regenerated organ had a similar structure to that found in a young mouse.

Function restored

The function of the thymus was also restored and the mice began making more white blood cells called T cells, which are important for fighting off infection. However, it is not yet clear whether the immune system of the mice was improved.

The study was led by researchers from the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh.

The researchers targeted a protein produced by cells of the thymus -- called FOXN1 -- which helps to control how important genes are switched on. By increasing levels of FOXN1, the team instructed stem cell-like cells to rebuild the organ.

"Our results suggest that targeting the same pathway in humans may improve thymus function and therefore boost immunity in elderly patients, or those with a suppressed immune system. However, before we test this in humans we need to carry out more work to make sure the process can be tightly controlled," said Clare Blackburn, Professor of Tissue Stem Cell Biology, MRC Centre for Regenerative Medicine.

Treatment hope

The thymus deteriorates with age, which is why older people are often more susceptible to infections such as flu.

The discovery could also offer hope to patients with DiGeorge syndrome, a genetic condition that causes the thymus to not develop properly.

"One of the key goals in regenerative medicine is harnessing the body's own repair mechanisms and manipulating these in a controlled way to treat disease. This interesting study suggests that organ regeneration in a mammal can be directed by manipulation of a single protein, which is likely to have broad implications for other areas of regenerative biology," said Dr Rob Buckle, Head of Regenerative Medicine, Medical Research Council.

The study is published today in the journal Development.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. Bredenkamp, C. S. Nowell, C. C. Blackburn. Regeneration of the aged thymus by a single transcription factor. Development, 2014; 141 (8): 1627 DOI: 10.1242/dev.103614

Cite This Page:

University of Edinburgh. "Living organ regenerated for first time: Thymus rebuilt in mice." ScienceDaily. ScienceDaily, 8 April 2014. <www.sciencedaily.com/releases/2014/04/140408115610.htm>.
University of Edinburgh. (2014, April 8). Living organ regenerated for first time: Thymus rebuilt in mice. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2014/04/140408115610.htm
University of Edinburgh. "Living organ regenerated for first time: Thymus rebuilt in mice." ScienceDaily. www.sciencedaily.com/releases/2014/04/140408115610.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins