Featured Research

from universities, journals, and other organizations

Biomarkers in HPV negative squamous-cell carcinomas of head, neck

Date:
April 8, 2014
Source:
Fox Chase Cancer Center
Summary:
A quartet of proteins that play critical roles in cell replication, cell death and DNA repair could lead to better targets for therapy against treatment-resistant head-and-neck squamous cell cancers, research suggests.

A quartet of proteins that play critical roles in cell replication, cell death, and DNA repair could lead to better targets for therapy against treatment-resistant head-and-neck squamous cell cancers.

In a study to be presented at the AACR Annual Meeting 2014 on Tuesday, April 8, Ranee Mehra, MD, a medical oncologist who specializes in head and neck cancers at Fox Chase Cancer Center, and colleagues, showed a correlation between the expression levels of these proteins in head-and-neck cancers negative for human papilloma virus (HPV). These tumors have a poorer prognosis than HPV-positive head-and-neck cancers.

The cancers arise in the cells that line moist surfaces in the mouth, including the lips, tongue, and gums, as well as the throat, larynx, and sinuses. The National Cancer Institute reports that some 75 percent of these cancers are caused by tobacco and alcohol use -- and that use of the two together are a greater risk than use of either separately.

Mehra's research could help determine potential treatments for head and neck cancers. "The ultimate goal would be to better understand a tumor's protein signature and underlying biology so that, in the future, we can better understand treatments are more likely to be beneficial to our patients with head and neck cancer."

She and colleagues looked at protein expression levels in samples from 101 cases of head-and-neck cancer banked from 1990 to 2002 in the Fox Chase tissue repository. One advantage of using this tissue, Mehra says, is that samples are cross-reference with patient treatment and survival data. Using tissue microarrays, which allow researchers to examine at a large number of samples at one time, the team looked for expression of ERCC-1, a DNA repair protein; survivin, a protein that inhibits programmed cell death or apoptosis; and two proteins active during cell division, Aurora A and phospho-Aurora A.

The research showed positive associations between expression of the repair protein ERCC1 and each cell-division protein, AuroraA (P < .0001) and phospho-Aurora (P = .0027). It also showed an association between both Aurora proteins (P < .0001). There was also an association between the apoptosis-regulator, survivin, and Aurora A (P = .0064), as well as survivin and ERCC1 (P = .0084).

A review of a publically available database examining mRNA expression levels for the four proteins showed a highly significant correlation between Aurora A and survivin (P = .002), confirming the protein microarray findings.

Survivin expression may prove a marker for improved survival, especially in patients who were treated with surgery plus radiation, Mehra said. She found that tumors with less than a median level of survivin expression were associated with improved patient survival compared to tumors with more than a median level of survivin (P = .03).

ERCC1 is already a potential prognostic biomarker for survival among patients treated with radiation after surgery. In a study published in Clinical Cancer Research last year, Mehra and colleagues found lower levels of ERCC1 predicted improved survival among patients treated with radiation.

"We hope to understand how these various pathways and mechanisms interrelate with each others. Understanding those pathways would help guide future research," Mehra said.


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Mehra, F. Zhu, D.-H. Yang, K. Q. Cai, J. Weaver, M. K. Singh, A. S. Nikonova, E. A. Golemis, D. B. Flieder, H. S. Cooper, M. Lango, J. A. Ridge, B. Burtness. Quantification of Excision Repair Cross-Complementing Group 1 and Survival in p16-Negative Squamous Cell Head and Neck Cancers. Clinical Cancer Research, 2013; 19 (23): 6633 DOI: 10.1158/1078-0432.CCR-13-0152

Cite This Page:

Fox Chase Cancer Center. "Biomarkers in HPV negative squamous-cell carcinomas of head, neck." ScienceDaily. ScienceDaily, 8 April 2014. <www.sciencedaily.com/releases/2014/04/140408162232.htm>.
Fox Chase Cancer Center. (2014, April 8). Biomarkers in HPV negative squamous-cell carcinomas of head, neck. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2014/04/140408162232.htm
Fox Chase Cancer Center. "Biomarkers in HPV negative squamous-cell carcinomas of head, neck." ScienceDaily. www.sciencedaily.com/releases/2014/04/140408162232.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins