Featured Research

from universities, journals, and other organizations

Immune system research may help predict who gets long-term complications from Lyme Disease

Date:
April 16, 2014
Source:
Johns Hopkins Medicine
Summary:
The groundwork has been laid for understanding how variations in immune responses to Lyme disease can contribute to the many different outcomes of this bacterial infection seen in individual patients. "Physicians have recognized for many years that Lyme disease is not a uniform disease process and can vary in outcomes," says the senior author of the report. "Our experiments have linked such differences to specific immune pathways controlled by elements of the immune system, which in turn might help us understand both the good immune processes that clear up the infection and the bad ones that cause injury and prolong symptoms. This could be a big step forward in managing this disease."

A team of scientists led by Johns Hopkins and Stanford University researchers has laid the groundwork for understanding how variations in immune responses to Lyme disease can contribute to the many different outcomes of this bacterial infection seen in individual patients. A report on the work appears online April 16 in PLOS One.

Related Articles


"Physicians have recognized for many years that Lyme disease is not a uniform disease process and can vary in outcomes," says Mark Soloski, Ph.D., a professor of medicine at the Johns Hopkins University School of Medicine and senior author of the report. "Our experiments have linked such differences to specific immune pathways controlled by elements of the immune system, which in turn might help us understand both the good immune processes that clear up the infection and the bad ones that cause injury and prolong symptoms. This could be a big step forward in managing this disease."

Lyme disease is caused by the bacterium Borrelia burgdorferi, which is transmitted to humans through the bite of infected ticks. The U.S. Centers for Disease Control and Prevention estimates that there are 300,000 new cases of Lyme disease a year. Symptoms can include fever, headache, fatigue and a characteristic circular, red skin rash called erythema migrans, which occurs early in the disease.

Arthritis, nervous system abnormalities and heart rhythm abnormalities can appear weeks or months after infection.

Although treatment with antibiotics usually restores pre-infection health within a few weeks, some patients develop post-treatment Lyme disease syndrome, whose symptoms include fatigue, pain or joint and muscle aches that can last for several months. The exact cause is not well understood, and the symptoms are difficult to treat, the researchers say.

In a bid to identify why symptoms persist in some patients and not others, the Johns Hopkins team searched for the biological "signature" of the early stages of Lyme disease by measuring the levels of immune system molecules, called cytokines, chemokines and acute phase makers -- proteins released by the liver as part of the process of inflammation. These molecules, which are also called mediators, orchestrate the complex interactions of the immune system response to infection, including inflammation.

Specifically, the team studied levels of 58 cytokines and chemokines plus seven acute phase markers in blood from 44 patients diagnosed with Lyme disease and 23 healthy people used as controls for comparison.

The team's analysis identified two subsets of Lyme disease in patients in the acute (early) stage of infection -- "mediator-high" and "mediator-low."

The levels of three chemokines in particular -- CXCL9, CXCL10 and CCL19 -- were increased in the mediator-high group and returned to normal levels after antibiotic treatment and the disappearance of the rash. Chemokines are small signaling molecules that attach to specific sites, called receptors, on a certain type of immune cells. These three chemokines in particular guide a type of immune cell called T lymphocytes into tissues to aid in the clearance of infection. The movement of T cells from the bloodstream to the site of infection also contributes to inflammation, which can cause tissue injury, Soloski notes. There was also an increase in the acute phase proteins released by the liver, including CRP and serum amyloid A.

Lyme disease patients displaying high mediator levels at the initial pretreatment visit (acute disease) also had more severe symptoms, higher rates of bacterial antibody production, greater rates of elevated liver enzymes and low blood lymphocytes levels. Elevated levels of liver enzyme activity are common during infection and other diseases and may indicate that the liver is a site of infection during human Lyme disease.

Individuals in the mediator-low group appear to represent Lyme disease patients who failed to mount a vigorous immune response, the researchers reported.

The results of the study indicate that the levels of chemokines in the blood and the levels of their specific receptors on the T cells they stimulate might prove to be important biomarkers for Lyme disease, and they could be linked to specific symptoms of the disease, Soloski says. Biomarkers are biological characteristics or molecules whose levels in the body or tissues can be measured to identify a specific biological state or condition (e.g., disease or response to therapy).

Although the study wasn't specifically designed to learn about post-treatment Lyme disease syndrome, the authors speculate that the variations in the pattern of mediators they observed strongly influence whether particular patients will recover from Lyme disease or develop long-term post-treatment symptoms.

"This study gives us basic data that will help us look for evidence of prolonged inflammation after completion of therapy and might, in the long term, help us identify biomarkers that predict that a particular person will develop post-treatment Lyme disease syndrome," Soloski says. "And since the chemokines that were elevated are key to the movement of T cells, blocking them might prevent them from moving into tissues and prolonging inflammation. This is one of the long-term aims of our work."


Story Source:

The above story is based on materials provided by Johns Hopkins Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark J. Soloski, Lauren A. Crowder, Lauren J. Lahey, Catriona A. Wagner, William H. Robinson, John N. Aucott. Serum Inflammatory Mediators as Markers of Human Lyme Disease Activity. PLoS ONE, 2014; 9 (4): e93243 DOI: 10.1371/journal.pone.0093243

Cite This Page:

Johns Hopkins Medicine. "Immune system research may help predict who gets long-term complications from Lyme Disease." ScienceDaily. ScienceDaily, 16 April 2014. <www.sciencedaily.com/releases/2014/04/140416171951.htm>.
Johns Hopkins Medicine. (2014, April 16). Immune system research may help predict who gets long-term complications from Lyme Disease. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2014/04/140416171951.htm
Johns Hopkins Medicine. "Immune system research may help predict who gets long-term complications from Lyme Disease." ScienceDaily. www.sciencedaily.com/releases/2014/04/140416171951.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins