Featured Research

from universities, journals, and other organizations

Adrenaline does little to increase patient's survival after cardiac arrest, study finds

Date:
April 17, 2014
Source:
St. Michael's Hospital
Summary:
Giving patients adrenaline after they suffer a cardiac arrest outside of a hospital does not increase their prospects of surviving long-term, according to new research. When a person has a cardiac arrest, his or her heart stops beating. Unless the heart is restarted within minutes, the person usually dies. More than 90 per cent of people who experience a cardiac arrest outside of a hospital will die before reaching a hospital or soon after.

Giving patients adrenaline after they suffer a cardiac arrest outside of a hospital does not increase their prospects of surviving long-term, according to new research conducted at St. Michael's Hospital.

Related Articles


"The vast number of patients who have a cardiac arrest get adrenaline, which has been the drug recommended in treating cardiac arrest for decades," said Dr. Steve Lin, an emergency physician and trauma team leader at St. Michael's. "Yet, despite advances in medical treatment, long-term survival rates of patients who suffer a cardiac outside a hospital and receive adrenaline remains low."

The findings were published in the journal Resuscitation.

When a person has a cardiac arrest, his or her heart stops beating. Unless the heart is restarted within minutes, the person usually dies. More than 90 per cent of people who experience a cardiac arrest outside of a hospital will die before reaching a hospital or soon after.

Dr. Lin and his colleagues looked at clinical trials and data involving out-of-hospital cardiac arrests that were published in medical journals up to July 2013 and found that adrenaline showed no benefit in survival to discharge from hospital or neurological outcomes.

"It is thought that the short-term benefit of adrenaline in improving coronary blood flow may occur at the expense of other organs," said Dr. Lin. "The drug can cause small blood vessels in other organs to contract, such as in the gut, liver, and kidneys, thus limiting the blood flow to these organs."

While adrenaline is also given to patients who suffer cardiac arrest in hospitals, Dr. Lin looked only at studies of those outside of a hospital because the cause of cardiac arrest tends to be different between the two settings. Those outside a hospital tend to be related to heart disease and heart attacks. Cardiac arrests in the hospital are usually related to the reasons why a patient would be in the hospital, such as infections or respiratory diseases.

Dr. Lin is a research fellow at Rescu -- a program based at St. Michael's that focuses on developing processes and interventions to improve outcomes for patients who suffer life- threatening trauma and cardiac emergencies outside of hospitals.

Dr. Lin said that because a standard dose of one milligram of adrenaline showed to be effective in regaining a person's pulse after a cardiac arrest, physicians also questioned what sort of impact a high dose of adrenaline might have.

"When compared to patients who received a standard dose of adrenaline, those who received a high dose had an even greater chance of regaining their pulse after a cardiac arrest," he said. "The long-term survival rate, however, did not increase."

Dr. Lin said that those in the medical community need to discuss and study whether adrenaline should still be administered during cardiac arrests. He recommends that paramedics focus on early use of defibrillators and effective CPR instead.

"The use of adrenaline has been the standard of care for so long that it's been hard to change the culture," said Dr. Lin. "We have reached a point in time where physicians and paramedics have to change the way we think."

Dr. Lin said about 40,000 Canadians suffer cardiac arrest outside of a hospital every year and that in Toronto, less than 10 per cent survive long enough to be discharged from hospital.


Story Source:

The above story is based on materials provided by St. Michael's Hospital. Note: Materials may be edited for content and length.


Cite This Page:

St. Michael's Hospital. "Adrenaline does little to increase patient's survival after cardiac arrest, study finds." ScienceDaily. ScienceDaily, 17 April 2014. <www.sciencedaily.com/releases/2014/04/140417124505.htm>.
St. Michael's Hospital. (2014, April 17). Adrenaline does little to increase patient's survival after cardiac arrest, study finds. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2014/04/140417124505.htm
St. Michael's Hospital. "Adrenaline does little to increase patient's survival after cardiac arrest, study finds." ScienceDaily. www.sciencedaily.com/releases/2014/04/140417124505.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins