Featured Research

from universities, journals, and other organizations

Proper stem cell function requires hydrogen sulfide

Date:
April 17, 2014
Source:
University of Southern California
Summary:
Stem cells in bone marrow need to produce hydrogen sulfide in order to properly multiply and form bone tissue, according to a new study. Researchers demonstrated that mice's osteoporosis-like condition could be rescued by administering small molecules that release hydrogen sulfide inside the body. The results indicate that a similar treatment may have potential to help human patients.

Professor Songtao Shi.
Credit: Image courtesy of University of Southern California

Stem cells in bone marrow need to produce hydrogen sulfide in order to properly multiply and form bone tissue, according to a new study from the Center for Craniofacial Molecular Biology at the Ostrow School of Dentistry.

Professor Songtao Shi, principal investigator on the project, said the presence of hydrogen sulfide produced by the cells governs the flow of calcium ions. The essential ions activate a chain of cellular signals that results in osteogenesis, or the creation of new bone tissue, and keeps the breakdown of old bone tissue at a proper level.

Conversely, having a hydrogen sulfide deficiency disrupted bone homeostasis and resulted in a condition similar to osteoporosis -- weakened, brittle bones -- in experimental mice. In humans, osteoporosis can cause serious problems such as bone fractures, mobility limitations and spinal problems; more than 52 million Americans have or are at risk for the disease.

However, Shi and his team demonstrated that the mice's condition could be rescued by administering small molecules that release hydrogen sulfide inside the body. The results indicate that a similar treatment may have potential to help human patients, Shi said.

"These results demonstrate hydrogen sulfide regulates bone marrow mesenchymal stem cells, and restoring hydrogen sulfide levels via non-toxic donors may provide treatments for diseases such as osteoporosis, which can arise from hydrogen sulfide deficiencies," Shi said.


Story Source:

The above story is based on materials provided by University of Southern California. The original article was written by Beth Newcomb. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yi Liu, Ruili Yang, Xibao Liu, Yu Zhou, Cunye Qu, Takashi Kikuiri, Songlin Wang, Ebrahim Zandi, Junbao Du, Indu S. Ambudkar, Songtao Shi. Hydrogen Sulfide Maintains Mesenchymal Stem Cell Function and Bone Homeostasis via Regulation of Ca2 Channel Sulfhydration. Cell Stem Cell, 2014; DOI: 10.1016/j.stem.2014.03.005

Cite This Page:

University of Southern California. "Proper stem cell function requires hydrogen sulfide." ScienceDaily. ScienceDaily, 17 April 2014. <www.sciencedaily.com/releases/2014/04/140417124708.htm>.
University of Southern California. (2014, April 17). Proper stem cell function requires hydrogen sulfide. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2014/04/140417124708.htm
University of Southern California. "Proper stem cell function requires hydrogen sulfide." ScienceDaily. www.sciencedaily.com/releases/2014/04/140417124708.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) — West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) — Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins