Featured Research

from universities, journals, and other organizations

Key steps linking dietary fats, colon cancer tumor growth

Date:
April 21, 2014
Source:
Arizona State University
Summary:
New genetic evidence that could strengthen the link between the role of dietary fats with colon cancer progression has been discovered by scientists. The study has identified a molecular culprit, called peroxisome proliferator-activated receptor delta, that, when deleted in a mouse model of colon cancer, stopped key steps required for the initiation and progression of tumor growth.

Scientists have shown new genetic evidence that could strengthen the link between the role of dietary fats with colon cancer progression.

Related Articles


The study, led by Arizona State University researcher and physician Dr. Raymond DuBois, M.D., Ph.D., has identified a molecular culprit, called peroxisome proliferator-activated receptor delta (PPAR delta), which, when deleted in a mouse model of colon cancer, stopped key steps required for the initiation and progression of tumor growth.

"This study has shown without a doubt there is a new function for a key molecule, PPAR delta, in the initiation and progression of colon cancer," said DuBois, executive director of ASU's Biodesign Institute. "These results also provide a new rationale for developing therapeutics that could block PPAR delta to treat inflammatory bowel disease and colorectal cancer."

The study was published in the April 21 early online edition of the Proceedings of the National Academy of Sciences. The research team included DuBois' Laboratory of Inflammation and Cancer members Dingzhi Wang, Lingchen Fu, Lixia Guo at ASU's Biodesign Institute; Wei Ning, Rupesh Chaturvedi, and Keith Wilson of Vanderbilt Medical School; and Xiaofei Sun and Sudhansu Dey of Cincinnati Childern's Research Foundation.

The DuBois research team has been in pursuit of uncovering the links between inflammation and colon cancer for the past 2 decades. Colorectal cancer is the second leading cause of cancer deaths in the U.S.

Evidence for this link comes from data showing that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduced the risk of developing colorectal cancer by 40-50 percent. NSAIDs target an enzyme called cyclooxygenase 2 (COX-2), which carries out steps to produce the pro-inflammatory molecule prostaglandin E2 (PGE2), found at high levels in colorectal tumors. DuBois' research team has long sought to uncover the key molecular steps regulating the COX-2/PGE2 pathway.

According to the Centers for Disease Control and Prevention, dietary components high in saturated fats such as red meat are thought to be risk factors for colon cancer. Other known epidemiological risk factors are family history, inflammatory bowel disease, smoking and type-2 diabetes.

The cell's garbage pail for dietary fat, is called the peroxisome. PPARs are central players in regulating the breakdown and storage of fats within a cell, and the DuBois team wanted to investigate the role one molecule, called PPAR delta, had on chronic inflammation and colorectal cancer progression.

In a mouse model of colon cancer, the team "knocked out" the gene to make PPAR, and found that the mice showed no clinical or cellular signs of chronic inflammation. Furthermore, when looking at the immune response, they found none of the usual immune cells associated with inflammation.

They also measured the levels of COX-2, and found that loss of PPAR had no effect on COX-2 expression. The found that PPAR required for induction of COX-2 expression and high levels of PGE2 production that are associated with inflammation and colon cancer.

"We found that both PPAR and COX-2-derived PGE2 signaling coordinately promote tumorigenesis. This is likely to be clinically relevant because the elevation of both PPAR delta and COX-2 in tumor tissues correlates with poor prognosis in colorectal cancer patients," said DuBois. "This provides us with an important new clue in designing and developing a therapeutic arsenal to stop the initiation and progression of colon cancer."


Story Source:

The above story is based on materials provided by Arizona State University. Note: Materials may be edited for content and length.


Cite This Page:

Arizona State University. "Key steps linking dietary fats, colon cancer tumor growth." ScienceDaily. ScienceDaily, 21 April 2014. <www.sciencedaily.com/releases/2014/04/140421151931.htm>.
Arizona State University. (2014, April 21). Key steps linking dietary fats, colon cancer tumor growth. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2014/04/140421151931.htm
Arizona State University. "Key steps linking dietary fats, colon cancer tumor growth." ScienceDaily. www.sciencedaily.com/releases/2014/04/140421151931.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins