Featured Research

from universities, journals, and other organizations

Stillbirth may be associated with both severely restricted and excessive fetal growth

Date:
April 22, 2014
Source:
PLOS
Summary:
When several factors are accounted for, stillbirth may be associated with both severely restricted and excessive fetal growth, according to a new study. Medical researchers investigated the fetal growth abnormalities associated with stillbirth using a new approach developed by the Stillbirth Collaborative Research Network to estimate gestational age.

When several factors are accounted for, stillbirth may be associated with both severely restricted and excessive fetal growth, according to a study by US researchers published in this week's PLOS Medicine.

Radek Bukowski and colleagues from the NICHD Stillbirth Collaborative Research Network investigated the fetal growth abnormalities associated with stillbirth using a new approach developed by the Stillbirth Collaborative Research Network to estimate gestational age.

Using this approach the authors investigated all the stillbirths, and a sample of live births, which occurred over 2 and a half years at 59 hospitals in five US regions.

The authors found that overall, abnormal fetal growth was identified in 25% of stillbirths using population norms and in above 50% of stillbirths using ultrasound or individualized norms: Small for Gestational Age (SGA: the bottom 10% of the population weight for gestational age) was associated with a 3- to 4-fold increased risk of stillbirth compared to having a fetus with "appropriate" weight for gestational age based on all three norms. Large for Gestational Age (LGA: the top 10% of the population weight for gestational age) was associated with an increased risk of stillbirth based on the ultrasound and individualized norms but not the population norms. Being more severely SGA or LGA (below the 5th percentile or above the 95th percentile) was associated with an increased risk of stillbirth.

Although the accuracy of these findings is likely to be affected by aspects of the study design, these findings suggest that, contrary to current practices, strategies designed to prevent stillbirth should focus on identifying both severely SGA and severely LGA fetuses.

The authors say: "When accounting for time of death and using norms developed in normal pregnancies, both SGA and LGA birth weights were associated with stillbirth in our study.

They continue: "The association is mainly related to severe SGA and LGA pregnancies, with birth weights either below the 5th or above the 95th percentile. Thus, classifying 10% of pregnancies as abnormally grown has the potential to identify 44%-46% of future stillbirths."


Story Source:

The above story is based on materials provided by PLOS. Note: Materials may be edited for content and length.


Journal Reference:

  1. Radek Bukowski, Nellie I. Hansen, Marian Willinger, Uma M. Reddy, Corette B. Parker, Halit Pinar, Robert M. Silver, Donald J. Dudley, Barbara J. Stoll, George R. Saade, Matthew A. Koch, Carol J. Rowland Hogue, Michael W. Varner, Deborah L. Conway, Donald Coustan, Robert L. Goldenberg. Fetal Growth and Risk of Stillbirth: A Population-Based Case–Control Study. PLoS Medicine, 2014; 11 (4): e1001633 DOI: 10.1371/journal.pmed.1001633

Cite This Page:

PLOS. "Stillbirth may be associated with both severely restricted and excessive fetal growth." ScienceDaily. ScienceDaily, 22 April 2014. <www.sciencedaily.com/releases/2014/04/140422202311.htm>.
PLOS. (2014, April 22). Stillbirth may be associated with both severely restricted and excessive fetal growth. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2014/04/140422202311.htm
PLOS. "Stillbirth may be associated with both severely restricted and excessive fetal growth." ScienceDaily. www.sciencedaily.com/releases/2014/04/140422202311.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins