Featured Research

from universities, journals, and other organizations

Identifying factors responsible for altered drug dosing for pregnant women

Date:
April 30, 2014
Source:
Federation of American Societies for Experimental Biology (FASEB)
Summary:
Pregnancy affects how drugs are metabolized, which makes it difficult for physicians to prescribe appropriate dosing. Medical researchers have revealed new details about one particular enzyme that’s responsible for the metabolism of one-fifth of drugs on the market.

More than 50% of pregnant women take at least one medication, and the average number of prescriptions per patient during pregnancy ranges from three to five. Pregnancy is known to alter the rate and extent of drug elimination posing a challenge to prescribers. At the same time, current obstetric guidelines promote the use of appropriate (i.e., "lowest effective") doses of drugs to prevent adverse outcomes in fetuses. However, determining "appropriate" dosing has been difficult as very little is understood about what causes these changes in drug disposition during pregnancy. A better understanding of altered drug disposition during pregnancy and its underlying mechanisms is critical to determine optimal dosage regimens in pregnant women.

Hyunyoung Jeong, an associate professor at the University of Illinois at Chicago, uses human liver cells to identify factors causing changes in the rate of hepatic drug elimination. Previously, her work highlighted important roles of multiple pregnancy hormones such as estrogens and progesterone in such changes. What she discovered is that most pregnancy hormones alter the expression of many enzymes involved in hepatic drug metabolism--but not an enzyme called CYP2D6. CYP2D6 is an important drug-metabolizing enzyme that is responsible for the elimination of 20% of marketed drugs. Jeong's latest study is the first to identify factors that govern CYP2D6 induction during pregnancy.

The study first established "CYP2D6-humanized mice" as a model to study CYP2D6 induction during pregnancy. These mice carry the human CYP2D6 gene so that the well-known interspecies difference in the genes of drug-metabolizing enzymes could be overcome. In the mice, a transcription factor called SHP was shown to exhibit decreased expression in the liver during pregnancy. Follow-up mechanistic studies revealed that SHP is a negative regulator of CYP2D6 expression, suggesting that decreased SHP expression may explain CYP2D6 induction during pregnancy. To identify upstream regulators of SHP that trigger the phenomenon, different factors that are known to alter SHP expression were screened. Hepatic levels of retinoic acid, a bioactive product of dietary vitamin A and an inducer of SHP expression, was decreased in mouse livers during pregnancy.

The identification of factors underlying CYP2D6 induction during pregnancy would be a major advance in improving drug therapy during pregnancy.

Dr. Jeong will present the findings during the Experimental Biology 2014 meeting on Sunday, April 30.

The study was funded by the National Institute of Child Health & Human Development.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology (FASEB). Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology (FASEB). "Identifying factors responsible for altered drug dosing for pregnant women." ScienceDaily. ScienceDaily, 30 April 2014. <www.sciencedaily.com/releases/2014/04/140430161303.htm>.
Federation of American Societies for Experimental Biology (FASEB). (2014, April 30). Identifying factors responsible for altered drug dosing for pregnant women. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2014/04/140430161303.htm
Federation of American Societies for Experimental Biology (FASEB). "Identifying factors responsible for altered drug dosing for pregnant women." ScienceDaily. www.sciencedaily.com/releases/2014/04/140430161303.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins