Featured Research

from universities, journals, and other organizations

Key protein behind aggressive forms of endometrial cancer

Date:
May 5, 2014
Source:
European Society of Endocrinology
Summary:
Aggressive forms of endometrial cancer are linked to high levels of a specific protein within cancer cells, according to research in a new study. The findings could allow researchers to slow down aggressive progression of this cancer, which was diagnosed in 320,000 women and caused 76,000 deaths worldwide in 2012.

Aggressive forms of endometrial cancer are linked to high levels of a specific protein within cancer cells, according to research presented at the European Congress of Endocrinology in Wrocłow, Poland. The findings could allow researchers to slow down aggressive progression of this cancer, which was diagnosed in 320,000 women and caused 76,000 deaths worldwide in 2012.

Endometrial cancer is the 14th most deadly cancer for women worldwide and affects 98,000 people in Europe. Around three quarters of cases are found in women aged over 55. The most common types of endometrial cancer are known as carcinomas. There are three grades of endometrial cancer based on how much the cancer forms glands that look similar to the glands found in normal, healthy endometrium. Grade 3 'high grade' cancers tend to be aggressive and are more likely to spread to other parts of the body. These types of cancer have a poor outlook.

In this study, a team of researchers from the National Yang-Ming University in Taipei compared different grades of endometrial carcinomas and normal endometrial tissues to find that endometrial carcinomas have higher levels of a protein called Neuromedin U (NMU). Previously, NMU has shown to play a role in muscle contraction, regulating blood pressure and appetite.

The researchers then investigated the role NMU by suppressing the NMU gene production in both high-graded and low-graded endometrial cancer cell lines. They found that the high-graded cancer cells were slower to grow and found it harder to move; this may reduce the likelihood of the aggressive cancer spreading to other parts of the body through metastasis.

"Our results show that high levels of NMU in endometrial cancer cells might maintain the ability of metastasis," said lead author of the study Mr Ting-Yu Lin. "This does not show that NMU causes grade 1 endometrial carcinomas to progress to grade 3 stage but does give us an insight into one of the potential causes of aggression."

Researchers will next test whether NMU has the same effect on the development of endometrial cancer in live mice. "If we can use NMU as a treatment target of high-graded endometrial carcinomas, we can slow down the level of cancer progression. This could potentially save lives."


Story Source:

The above story is based on materials provided by European Society of Endocrinology. Note: Materials may be edited for content and length.


Cite This Page:

European Society of Endocrinology. "Key protein behind aggressive forms of endometrial cancer." ScienceDaily. ScienceDaily, 5 May 2014. <www.sciencedaily.com/releases/2014/05/140505211242.htm>.
European Society of Endocrinology. (2014, May 5). Key protein behind aggressive forms of endometrial cancer. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2014/05/140505211242.htm
European Society of Endocrinology. "Key protein behind aggressive forms of endometrial cancer." ScienceDaily. www.sciencedaily.com/releases/2014/05/140505211242.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins