Featured Research

from universities, journals, and other organizations

5-year survival of diabetes and non-diabetes patients post-kidney transplant now nearly equal

Date:
May 6, 2014
Source:
Mayo Clinic
Summary:
The five-year survival of diabetic kidney transplant patients is now on par with the five-year survival of nondiabetic kidney recipients, researchers have found. The study findings represent significant improvements in the management of kidney transplant patients who have diabetes and pre-transplant consequences of diabetes such as heart disease and high blood pressure. The study also suggests that improvements in patient management post-transplant have resulted in significant declines in subsequent cardiac events and a reduction in infections.

Mayo Clinic researchers have discovered that the five-year survival of diabetic kidney transplant patients is now on par with the five-year survival of nondiabetic kidney recipients.

These new findings are published on the Kidney International website and will also be printed in a future issue of the journal.

The study findings represent significant improvements in the management of kidney transplant patients who have diabetes and pre-transplant consequences of diabetes such as heart disease and high blood pressure. The study also suggests that improvements in patient management post-transplant have resulted in significant declines in subsequent cardiac events and a reduction in infections. Prior to 2004, the five-year mortality rate of diabetic kidney transplant patients was more than double that of nondiabetic kidney recipients.

To arrive at these latest findings, a Mayo Clinic research team led by Fernando Cosio, M.D., medical director of kidney and pancreas transplantation, analyzed the experiences of 1,688 kidney recipients, including 413 with diabetes prior to transplant between 1996 and 2007.

The survival of patients with diabetes mellitus in the general population has improved in recent years. Post-transplant, patients with diabetes experienced a significant decline in major fatal/nonfatal cardiac events and deaths from infections over time. In contrast, neither cardiac events nor overall mortality declined in recipients who did not have diabetes. The decline in mortality due to diabetes did not relate to a reduced pre-transplant risk profile and was independent of post-transplant variables. The use of cardioprotective medications and glycemic control improved over time post-transplant. Furthermore, graft function and serum albumin significantly improved over time, and these parameters related to better survival.

"We were really encouraged to see this gap improve so dramatically," says Dr. Cosio. "Diabetic patients who undergo kidney transplantation can expect outcomes equally as successful as nondiabetics, provided that they are diligent in their management of blood pressure, glucose, healthy weight, and other factors that influence their kidney function and overall well-being."

The Mayo Clinic research team also included Mira Keddis, M.D., Nephrology; Mireille El Ters, M.D.; Emilio Rodrigo, M.D., Ph.D.; Patrick Dean, M.D., Transplantation Surgery; Mariana Wohlfahrtova, M.D.; Yogish Kudva, M.B.B.S., Endocrinology; Elizabeth Lorenz, M.D., Nephrology and Hypertension.

More than 120,000 people are waiting for organ transplant in the United States. Nearly 2,000 of those are children. Every 10 minutes another name is added to the national waiting list. An average of 18 people die each day in the United States waiting for transplants that can't take place because of the shortage of donated organs.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mira T Keddis, Mireille El Ters, Emilio Rodrigo, Patrick Dean, Mariana Wohlfahrtova, Yogish C Kudva, Elizabeth C Lorenz, Fernando G Cosio. Enhanced posttransplant management of patients with diabetes improves patient outcomes. Kidney International, 2014; DOI: 10.1038/ki.2014.70

Cite This Page:

Mayo Clinic. "5-year survival of diabetes and non-diabetes patients post-kidney transplant now nearly equal." ScienceDaily. ScienceDaily, 6 May 2014. <www.sciencedaily.com/releases/2014/05/140506161236.htm>.
Mayo Clinic. (2014, May 6). 5-year survival of diabetes and non-diabetes patients post-kidney transplant now nearly equal. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2014/05/140506161236.htm
Mayo Clinic. "5-year survival of diabetes and non-diabetes patients post-kidney transplant now nearly equal." ScienceDaily. www.sciencedaily.com/releases/2014/05/140506161236.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins