Featured Research

from universities, journals, and other organizations

Urine test best detects alcohol use in liver transplant candidates, recipients

Date:
May 8, 2014
Source:
Wiley
Summary:
Urinary ethyl glucuronide (uEtG) accurately detects alcohol consumption in liver transplant candidates and recipients, researchers have confirmed. The study suggests that a combination of uEtG and the Alcohol Use Disorders Identification Test for alcohol consumption (AUDIT-c) are best in alerting doctors to alcohol consumption by patients undergoing evaluation for liver transplantation or who have received liver transplants.

Researchers from Italy confirm that urinary ethyl glucuronide (uEtG) accurately detects alcohol consumption in liver transplant candidates and recipients. The study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, suggests that a combination of uEtG and the Alcohol Use Disorders Identification Test for alcohol consumption (AUDIT-c) are best in alerting doctors to alcohol consumption by patients undergoing evaluation for liver transplantation or who have received liver transplants.

Related Articles


Alcoholic liver disease is one of the most common reasons for liver transplantation in Europe and the U.S say experts. Furthermore, studies suggest that up to 49% of liver transplant recipients struggle with alcohol relapse, which may cause complications with the graft. In fact, medical evidence found that transplant recipients who relapse have a poorer survival rate than abstinent patients.

"Assessing alcohol consumption is crucial in the selection of liver transplant candidates," explains Dr. Paolo Angeli from the University of Padova in Italy. "Equally important is the ability to detect alcohol use in liver transplant recipients so early intervention for alcohol relapse can take place."

For the present study the research team evaluated the effectiveness of uEtg, AUDIT-c, serum ethanol (sETOH), urinary ethanol (uETOH), and carbohydrate-deficient transferrin (CDT) in assessing drinking status in 121 liver transplant candidates and recipients. Participants provided blood and urine samples at each visit to detect all alcohol markers.

Researchers detected alcohol consumption in 31% of participants, with uEtG found to be the strongest marker of alcohol use. Compared to CDT, uEtG was also more accurate in predicting the amount of alcohol consumption. When used together uEtG and AUDIT-c were more accurate in assessing alcohol consumption than CDT and AUDIT-c. In patients with a negative AUDIT-c, uEtG was the most effective indicator of drinking status.

The authors recommend that AUDIT-c and uEtG be routinely used in transplant candidates and recipients to monitor drinking status. Dr. Angeli concludes, "It's vital that patients abstain from damaging drinking behavior following liver transplant to avoid graft loss or even death. When used together, uEtG and AUDIT-c provide an important tool in the management of transplant patients at risk for alcohol relapse."


Story Source:

The above story is based on materials provided by Wiley. Note: Materials may be edited for content and length.


Journal Reference:

  1. Salvatore Piano, Lucio Marchioro, Elisabetta Gola, Silvia Rosi, Filippo Morando, Marta Cavallin, Antonietta Sticca, Silvano Fasolato, Giovanni Forza, Anna Chiara Frigo, Mario Plebani, Giacomo Zanus, Umberto Cillo, Angelo Gatta, Paolo Angeli. Assessment of alcohol consumption in liver transplant candidates and recipients: the best combination among the tools available. Liver Transplantation, 2014; DOI: 10.1002/lt.23881

Cite This Page:

Wiley. "Urine test best detects alcohol use in liver transplant candidates, recipients." ScienceDaily. ScienceDaily, 8 May 2014. <www.sciencedaily.com/releases/2014/05/140508095413.htm>.
Wiley. (2014, May 8). Urine test best detects alcohol use in liver transplant candidates, recipients. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2014/05/140508095413.htm
Wiley. "Urine test best detects alcohol use in liver transplant candidates, recipients." ScienceDaily. www.sciencedaily.com/releases/2014/05/140508095413.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins