Featured Research

from universities, journals, and other organizations

Radiotherapy: Novel lung cancer treatment meets with success

Date:
May 8, 2014
Source:
Wake Forest Baptist Medical Center
Summary:
An old idea of retreating lung tumors with radiation is new again, especially with the technological advances seen in radiation oncology over the last decade. “One of the toughest challenges of lung cancer is what to do for patients when the cancer comes back in an area that’s been treated previously with radiation treatment,” said the lead author. “With some of the technological advances in radiation treatments that have occurred in the last five to 10 years, we’re beginning to re-look at the issue and ask – can we target the radiation precisely enough and with a high enough dose to knock the cancer back?”

An old idea of retreating lung tumors with radiation is new again, especially with the technological advances seen in radiation oncology over the last decade.

The Comprehensive Cancer Center of Wake Forest Baptist Medical Center is one of only a handful of cancer centers that is attempting to give lung cancer patients out of treatment options a chance to keep the cancer at bay. For these patients, hope lies in a second course of treatment – repeat radiation. Two complementary papers published back-to-back recently in the journal Radiotherapy and Oncology and the Journal of Thoracic Oncology outline the treatment success at Wake Forest Baptist.

“One of the toughest challenges of lung cancer is what to do for patients when the cancer comes back in an area that’s been treated previously with radiation treatment,” said James J. Urbanic, M.D., lead author of the studies and a radiation oncologist at Wake Forest Baptist. “With some of the technological advances in radiation treatments that have occurred in the last five to 10 years, we’re beginning to re-look at the issue and ask – can we target the radiation precisely enough and with a high enough dose to knock the cancer back?”

Urbanic said the overall findings of the study suggest that there are some patients with recurrent lung cancers who can be treated with another definitive course of radiation therapy and still have a chance at a cure. “At many cancer treatment centers, these patients only get chemotherapy and have no chance at definitive treatment. The goal of treatment is solely to prevent or delay symptoms from developing and they are seen as incurable,” he said. “But with re-irradiation, our study shows that maybe we can give a curative intent treatment that we couldn’t do in the past. It’s a layer of hope for some patients that they never had before.”

For this study, the researchers looked back at 11 years of clinical data. Eighty-six patients were identified who received at least two courses of thoracic radiotherapy. Of that number, 33 were treated with repeat thoracic radiotherapy using stereotactic body radiation therapy (SBRT) or accelerated hypofractionated radiotherapy (AHRT), as a component of their treatment. The median age was 66 and the majority of patients (88 percent) were treated for primary lung cancer. Average tumor size at retreatment was 2.5 cm. Prior lung resections had been completed in 24 percent of patients.

Urbanic said the typical patient is an older man or woman who got treated with either chemotherapy and radiation or radiation alone for a lung cancer that couldn’t be surgically removed. They’ve returned for a checkup and feel well, but a CT scan shows that the cancer has returned in the area previously treated. If the cancer is just in one spot, the patients get retreated with 10 radiation treatments done with the SBRT technique which is tightly targeted to just the tumor and minimizes the dose to the surrounding normal tissue.

“Wake Forest Baptist has been developing expertise in doing this,” Urbanic said. “We’re finding that there are patients who are alive years later. We have seen relatively modest toxicity and a good ability to try and control the disease – upwards of 70 percent of the time.”

But there is a higher risk of injury involved when someone is radiated a second time which is why other cancer treatment center programs might be reluctant to adopt the practice, he said.

“This is a fairly niche effort in lung cancer care, and we’d like to see a national level clinical trial at some point,” he said. “The technology has gotten to the point where I think it’s going to allow radiation oncologists to reassess their ability so that maybe they can take risks they weren’t willing to take before. Eventually, this practice will become more widespread.”


Story Source:

The above story is based on materials provided by Wake Forest Baptist Medical Center. Note: Materials may be edited for content and length.


Journal References:

  1. Jeremy M. Kilburn, Jeffrey G. Kuremsky, A. William Blackstock, Michael T. Munley, William T. Kearns, William H. Hinson, James F. Lovato, Antonius A. Miller, William J. Petty, James J. Urbanic. Thoracic re-irradiation using stereotactic body radiotherapy (SBRT) techniques as first or second course of treatment. Radiotherapy and Oncology, 2014; 110 (3): 505 DOI: 10.1016/j.radonc.2013.11.017
  2. Jeremy M. Kilburn, Scott C. Lester, John T. Lucas, Michael H. Soike, A. William Blackstock, William T. Kearns, William H. Hinson, Antonius A. Miller, William J. Petty, Michael T. Munley, James J. Urbanic. Management of Mediastinal Relapse after Treatment with Stereotactic Body Radiotherapy or Accelerated Hypofractionated Radiotherapy for Stage I/II Non–Small-Cell Lung Cancer. Journal of Thoracic Oncology, 2014; 9 (4): 572 DOI: 10.1097/JTO.0000000000000086

Cite This Page:

Wake Forest Baptist Medical Center. "Radiotherapy: Novel lung cancer treatment meets with success." ScienceDaily. ScienceDaily, 8 May 2014. <www.sciencedaily.com/releases/2014/05/140508121251.htm>.
Wake Forest Baptist Medical Center. (2014, May 8). Radiotherapy: Novel lung cancer treatment meets with success. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2014/05/140508121251.htm
Wake Forest Baptist Medical Center. "Radiotherapy: Novel lung cancer treatment meets with success." ScienceDaily. www.sciencedaily.com/releases/2014/05/140508121251.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins