Featured Research

from universities, journals, and other organizations

Lung microbes protect against asthma

Date:
May 15, 2014
Source:
Swiss National Science Foundation (SNSF)
Summary:
Whether or not people develop asthma may be determined in the first few weeks after birth according to a study of mice. The study suggests that microbes in the lungs stimulate the newborn's immune system. Our lungs were long considered to be germfree and sterile. It was only recently discovered that, like our intestines and skin, our respiratory organs are colonized by bacteria. Now, tests conducted on mice have shown that these lung microbes offer protection against allergic asthma.

Whether or not people develop asthma may be determined in the first few weeks after birth according to a study of mice funded by the Swiss National Science Foundation (SNSF). The study suggests that microbes in the lungs stimulate the newborn's immune system.

Our lungs were long considered to be germfree and sterile. It was only recently discovered that, like our intestines and skin, our respiratory organs are colonised by bacteria. Now, tests conducted on mice by researchers working with Benjamin Marsland at the University Hospital in Lausanne have shown that these lung microbes offer protection against allergic asthma.

The researchers exposed the mice to an extract obtained from house dust mites. Neonates had a much stronger allergic reaction to the extract than older mice. Why? The lungs in newborn mice have not yet been colonised by the microbes that alter the immune system and make its responses less prone to allergic reactions.

Two-week adaptation process

The researchers have discovered that the process of colonisation and adaptation takes place during the first two weeks of the mouse's life. Young mice that were kept completely germ-free remained susceptible to asthma and had excessive immune responses to dust mite allergens even later in life.

Marsland and his team have already started studying whether lung microbes ensure healthy airways in humans as well. Pilot studies involving newborn babies in Switzerland and New Zealand indicate that the situation may be similar for men and mice. Further studies are required, however, to identify the potential mechanisms in humans.

Focus on newborns

"There would appear to be a developmental window early in life that determines whether or not an individual will develop asthma later," Marsland says. Until now, scientists and doctors have focused on asthma essentially from the point of view of the course of the disease and possible direct triggers. "We should probably focus on a much earlier stage, that of newborns."

What Marsland wants to know now is how big the developmental window is for building up the immune system in childhood. He hopes that the new discovery will help prevent asthma. Perhaps by encouraging pregnant women to eat more fruit and vegetables -- quite recently Marsland showed that the dietary fibre contained in these foodstuffs also protects against allergic asthma by altering the microbial flora. That protection might be passed on to newborn babies.


Story Source:

The above story is based on materials provided by Swiss National Science Foundation (SNSF). Note: Materials may be edited for content and length.


Journal Reference:

  1. Eva S Gollwitzer, Sejal Saglani, Aurιlien Trompette, Koshika Yadava, Rebekah Sherburn, Kathy D McCoy, Laurent P Nicod, Clare M Lloyd, Benjamin J Marsland. Lung microbiota promotes tolerance to allergens in neonates via PD-L1. Nature Medicine, 2014; DOI: 10.1038/nm.3568

Cite This Page:

Swiss National Science Foundation (SNSF). "Lung microbes protect against asthma." ScienceDaily. ScienceDaily, 15 May 2014. <www.sciencedaily.com/releases/2014/05/140515090801.htm>.
Swiss National Science Foundation (SNSF). (2014, May 15). Lung microbes protect against asthma. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2014/05/140515090801.htm
Swiss National Science Foundation (SNSF). "Lung microbes protect against asthma." ScienceDaily. www.sciencedaily.com/releases/2014/05/140515090801.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) — California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) — The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins