Featured Research

from universities, journals, and other organizations

Intake of dietary methyl donors in first trimester affects asthma risk in children

Date:
May 19, 2014
Source:
American Thoracic Society
Summary:
Maternal intake of dietary methyl donors during the first trimester of pregnancy modulates the risk of developing childhood asthma at age 7, according to a new study. Methyl donors are nutrients involved in a biochemical process called methylation, in which chemicals are linked to proteins, DNA, or other molecules in the body. This process is involved in a number of important functions in the body, and dietary intake of methyl donors has been shown to affect the risk of developing a number of diseases, including heart disease and cancer.

Maternal intake of dietary methyl donors during the first trimester of pregnancy modulates the risk of developing childhood asthma at age 7, according to a new study presented at the 2014 American Thoracic Society International Conference.

Related Articles


"Evidence on the effects of dietary methyl donor intake on childhood asthma has been mixed," said lead author Michelle Trivedi, MD, Clinical Fellow in Pediatric Pulmonology at Massachusetts General Hospital for Children in Boston. "It has been suggested that folate enrichment of some foods may have contributed to the increasing asthma and allergy prevalence in the US. In our study of more than a one thousand mother-child pairs, we found that maternal intake of the six methyl donors we studied, folate, choline, betaine, and vitamins B2, B6, and B12, had protective effects on the risk of developing childhood asthma, and that interactions between these nutrients affected the magnitude and the direction of this risk."

Methyl donors are nutrients involved in a biochemical process called methylation, in which chemicals are linked to proteins, DNA, or other molecules in the body. This process is involved in a number of important functions in the body, and dietary intake of methyl donors has been shown to affect the risk of developing a number of diseases, including heart disease and cancer.

In the current study, maternal dietary and supplemental methyl donor intake was assessed with food-frequency questionnaires in the first and second trimesters in 1,052 mother-child pairs. Of the 1,052 children, 219 (20.8%) were diagnosed with asthma at age 7.

In analyses adjusting for age, body mass index, asthma, education, and household income of the mother along with the birth weight, sex, race/ethnicity, duration of breastfeeding, exposure to environmental tobacco smoke, and eczema of the child, only dietary vitamin B12 and choline in the first trimester were associated with lower asthma prevalence at age 7.

"Our results suggest that dietary intake of folate and other methyl donors during pregnancy does not increase the risk for asthma and may, in fact, decrease the risk of offspring developing asthma," said Dr. Trivedi. "Further study is warranted to dissect potential mechanisms."

Dr. Trivedi's group is planning further research on the mechanisms by which folate and other methyl donors affect the methylation status of DNA.


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Intake of dietary methyl donors in first trimester affects asthma risk in children." ScienceDaily. ScienceDaily, 19 May 2014. <www.sciencedaily.com/releases/2014/05/140519184542.htm>.
American Thoracic Society. (2014, May 19). Intake of dietary methyl donors in first trimester affects asthma risk in children. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2014/05/140519184542.htm
American Thoracic Society. "Intake of dietary methyl donors in first trimester affects asthma risk in children." ScienceDaily. www.sciencedaily.com/releases/2014/05/140519184542.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins