Featured Research

from universities, journals, and other organizations

Promising discovery in fight against antibiotic-resistant bacteria

Date:
May 22, 2014
Source:
University of British Columbia
Summary:
A small molecule that prevents bacteria from forming into biofilms, a frequent cause of infections, has been discovered by researchers. The anti-biofilm peptide works on a range of bacteria including many that cannot be treated by antibiotics. "Currently there is a severe problem with antibiotic-resistant organisms," says the lead author of the study. "Our entire arsenal of antibiotics is gradually losing effectiveness."

UBC’s Bob Hancock and his team of researchers have discovered a peptide that could help destroy biofilms, which are responsible for two-thirds of human infections.
Credit: Martin Dee

Researchers at the University of British Columbia have identified a small molecule that prevents bacteria from forming into biofilms, a frequent cause of infections. The anti-biofilm peptide works on a range of bacteria including many that cannot be treated by antibiotics.

"Currently there is a severe problem with antibiotic-resistant organisms," says Bob Hancock, a professor in UBC's Dept. of Microbiology and Immunology and lead author of the study published today in PLOS Pathogens. "Our entire arsenal of antibiotics is gradually losing effectiveness."

Many bacteria that grow on skin, lung, heart and other human tissue surfaces form biofilms, highly structured communities of bacteria that are responsible for two-thirds of all human infections. There are currently no approved treatments for biofilm infections and bacteria in biofilms are considerably more resistant to standard antibiotics.

Hancock and his colleagues found that the peptide known as 1018 -- consisting of just 12 amino acids, the building blocks of protein -- destroyed biofilms and prevented them from forming.

Bacteria are generally separated into two classes, Gram-positives and Gram-negatives, and the differences in their cell wall structures make them susceptible to different antibiotics. 1018 worked on both classes of bacteria as well as several major antibiotic-resistant pathogens, including Pseudomonas aeruginosa, E. coli and MRSA.

"Antibiotics are the most successful medicine on the planet. The lack of effective antibiotics would lead to profound difficulties with major surgeries, some chemotherapy treatments, transplants, and even minor injuries," says Hancock. "Our strategy represents a significant advance in the search for new agents that specifically target bacterial biofilms."


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cιsar de la Fuente-Nϊρez, Fany Reffuveille, Evan F. Haney, Suzana K. Straus, Robert E. W. Hancock. Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response. PLoS Pathogens, 2014; 10 (5): e1004152 DOI: 10.1371/journal.ppat.1004152

Cite This Page:

University of British Columbia. "Promising discovery in fight against antibiotic-resistant bacteria." ScienceDaily. ScienceDaily, 22 May 2014. <www.sciencedaily.com/releases/2014/05/140522175719.htm>.
University of British Columbia. (2014, May 22). Promising discovery in fight against antibiotic-resistant bacteria. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2014/05/140522175719.htm
University of British Columbia. "Promising discovery in fight against antibiotic-resistant bacteria." ScienceDaily. www.sciencedaily.com/releases/2014/05/140522175719.htm (accessed October 20, 2014).

Share This



More Plants & Animals News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) — Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) — He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) — An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Hey, Doc! Sewage, Beer and Food Scraps Can Power Chevrolet’s Bi-Fuel Impala

Hey, Doc! Sewage, Beer and Food Scraps Can Power Chevrolet’s Bi-Fuel Impala

3BL Media (Oct. 20, 2014) — Hey, Doc! Sewage, Beer and Food Scraps Can Power Chevrolet’s Bi-fuel Impala Video provided by 3BL
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins