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Promising discovery in fight against antibiotic-resistant bacteria

Date:
May 22, 2014
Source:
University of British Columbia
Summary:
A small molecule that prevents bacteria from forming into biofilms, a frequent cause of infections, has been discovered by researchers. The anti-biofilm peptide works on a range of bacteria including many that cannot be treated by antibiotics. "Currently there is a severe problem with antibiotic-resistant organisms," says the lead author of the study. "Our entire arsenal of antibiotics is gradually losing effectiveness."

UBC’s Bob Hancock and his team of researchers have discovered a peptide that could help destroy biofilms, which are responsible for two-thirds of human infections.
Credit: Martin Dee

Researchers at the University of British Columbia have identified a small molecule that prevents bacteria from forming into biofilms, a frequent cause of infections. The anti-biofilm peptide works on a range of bacteria including many that cannot be treated by antibiotics.

"Currently there is a severe problem with antibiotic-resistant organisms," says Bob Hancock, a professor in UBC's Dept. of Microbiology and Immunology and lead author of the study published today in PLOS Pathogens. "Our entire arsenal of antibiotics is gradually losing effectiveness."

Many bacteria that grow on skin, lung, heart and other human tissue surfaces form biofilms, highly structured communities of bacteria that are responsible for two-thirds of all human infections. There are currently no approved treatments for biofilm infections and bacteria in biofilms are considerably more resistant to standard antibiotics.

Hancock and his colleagues found that the peptide known as 1018 -- consisting of just 12 amino acids, the building blocks of protein -- destroyed biofilms and prevented them from forming.

Bacteria are generally separated into two classes, Gram-positives and Gram-negatives, and the differences in their cell wall structures make them susceptible to different antibiotics. 1018 worked on both classes of bacteria as well as several major antibiotic-resistant pathogens, including Pseudomonas aeruginosa, E. coli and MRSA.

"Antibiotics are the most successful medicine on the planet. The lack of effective antibiotics would lead to profound difficulties with major surgeries, some chemotherapy treatments, transplants, and even minor injuries," says Hancock. "Our strategy represents a significant advance in the search for new agents that specifically target bacterial biofilms."


Story Source:

The above story is based on materials provided by University of British Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cιsar de la Fuente-Nϊρez, Fany Reffuveille, Evan F. Haney, Suzana K. Straus, Robert E. W. Hancock. Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response. PLoS Pathogens, 2014; 10 (5): e1004152 DOI: 10.1371/journal.ppat.1004152

Cite This Page:

University of British Columbia. "Promising discovery in fight against antibiotic-resistant bacteria." ScienceDaily. ScienceDaily, 22 May 2014. <www.sciencedaily.com/releases/2014/05/140522175719.htm>.
University of British Columbia. (2014, May 22). Promising discovery in fight against antibiotic-resistant bacteria. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2014/05/140522175719.htm
University of British Columbia. "Promising discovery in fight against antibiotic-resistant bacteria." ScienceDaily. www.sciencedaily.com/releases/2014/05/140522175719.htm (accessed July 25, 2014).

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