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'Nanodaisies' deliver drug cocktail to cancer cells

Date:
May 28, 2014
Source:
North Carolina State University
Summary:
Daisy-shaped, nanoscale structures that are made predominantly of anti-cancer drugs and are capable of introducing a 'cocktail' of multiple drugs into cancer cells, biomedical engineering researchers report. Once injected, the nanodaisies float through the bloodstream until they are absorbed by cancer cells. Once in a cancer cell, the drugs are released.

Early tests of the “nanodaisy” drug delivery technique show promise against a number of cancers.
Credit: Ran Mo

Biomedical engineering researchers have developed daisy-shaped, nanoscale structures that are made predominantly of anti-cancer drugs and are capable of introducing a "cocktail" of multiple drugs into cancer cells. The researchers are all part the joint biomedical engineering program at North Carolina State University and the University of North Carolina at Chapel Hill.

"We found that this technique was much better than conventional drug-delivery techniques at inhibiting the growth of lung cancer tumors in mice," says Dr. Zhen Gu, senior author of the paper and an assistant professor in the joint biomedical engineering program. "And based on in vitro tests in nine different cell lines, the technique is also promising for use against leukemia, breast, prostate, liver, ovarian and brain cancers."

To make the "nanodaisies," the researchers begin with a solution that contains a polymer called polyethylene glycol (PEG). The PEG forms long strands that have much shorter strands branching off to either side. Researchers directly link the anti-cancer drug camptothecin (CPT) onto the shorter strands and introduce the anti-cancer drug doxorubicin (Dox) into the solution.

PEG is hydrophilic, meaning it likes water. CPT and Dox are hydrophobic, meaning they don't like water. As a result, the CPT and Dox cluster together in the solution, wrapping the PEG around themselves. This results in a daisy-shaped drug cocktail, only 50 nanometers in diameter, which can be injected into a cancer patient.

Once injected, the nanodaisies float through the bloodstream until they are absorbed by cancer cells. In fact, one of the reasons the researchers chose to use PEG is because it has chemical properties that prolong the life of the drugs in the bloodstream.

Once in a cancer cell, the drugs are released. "Both drugs attack the cell's nucleus, but via different mechanisms," says Dr. Wanyi Tai, lead author and a former postdoctoral researcher in Gu's lab.

"Combined, the drugs are more effective than either drug is by itself," Gu says. "We are very optimistic about this technique and are hoping to begin pre-clinical testing in the near future."


Story Source:

The above story is based on materials provided by North Carolina State University. The original article was written by Matt Shipman. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wanyi Tai, Ran Mo, Yue Lu, Tianyue Jiang, Zhen Gu. Folding graft copolymer with pendant drug segments for co-delivery of anticancer drugs. Biomaterials, 2014; DOI: 10.1016/j.biomaterials.2014.05.004

Cite This Page:

North Carolina State University. "'Nanodaisies' deliver drug cocktail to cancer cells." ScienceDaily. ScienceDaily, 28 May 2014. <www.sciencedaily.com/releases/2014/05/140528105304.htm>.
North Carolina State University. (2014, May 28). 'Nanodaisies' deliver drug cocktail to cancer cells. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/05/140528105304.htm
North Carolina State University. "'Nanodaisies' deliver drug cocktail to cancer cells." ScienceDaily. www.sciencedaily.com/releases/2014/05/140528105304.htm (accessed July 31, 2014).

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