Featured Research

from universities, journals, and other organizations

Why some experimental forms of 'The Pill for Males' will never rise to the occasion

Date:
June 2, 2014
Source:
Federation of American Societies for Experimental Biology
Summary:
It appears that 'The Pill' for men will have to wait a while longer. A new research study involving mice shows that a previously developed male hormonal oral contraceptive method (i.e. via testosterone) is unable to stop the production and/or release of sperm. Scientists demonstrated that the male contraception approach by testosterone has an inherent problem -- spermatogenesis does not stop. They found that that administering increasing doses of testosterone to infertile mutant mice did allow sexual function to return at a certain dosing threshold, however spermatogenesis also returned at that dose.

It appears that "The Pill" for men will have to wait a while longer. A new research report published in the June 2014 issue of The FASEB Journal involving mice, shows that a previously developed male hormonal oral contraceptive method (i.e. via testosterone) is unable to stop the production and / or the release of sperm.

"Our research in mice explains why the efficacy of male hormonal contraception is not as effective as expected and it provides clues on how to improve the method," said Ilpo Huhtaniemi, M.D., Ph.D., M.D.hc, FMed.Sci., a researcher involved in the work from the Institute of Reproductive and Developmental Biology at the Imperial College of London in London, UK.

Scientists demonstrated in experimental mice that the male contraception approach by testosterone has an inherent problem -- spermatogenesis does not stop. They found that that administering increasing doses of testosterone to infertile mutant mice did allow sexual function to return at a certain dosing threshold, which was expected. What was not expected, however, is that spermatogenesis also returned at that dose. This suggests that it is impossible to give a single dose of testosterone that allows for sexual function and the suppression of pituitary gonadotropin secretion, but also does not initiate sperm production.

"Ever since The Pill was developed, we've been aiming for an equivalent for men," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This report suggests that we may be finally reaching the end of administering testosterone for this purpose."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. O. O. Oduwole, N. Vydra, N. E. M. Wood, L. Samanta, L. Owen, B. Keevil, M. Donaldson, K. Naresh, I. T. Huhtaniemi. Overlapping dose responses of spermatogenic and extragonadal testosterone actions jeopardize the principle of hormonal male contraception. The FASEB Journal, 2014; 28 (6): 2566 DOI: 10.1096/fj.13-249219

Cite This Page:

Federation of American Societies for Experimental Biology. "Why some experimental forms of 'The Pill for Males' will never rise to the occasion." ScienceDaily. ScienceDaily, 2 June 2014. <www.sciencedaily.com/releases/2014/06/140602101704.htm>.
Federation of American Societies for Experimental Biology. (2014, June 2). Why some experimental forms of 'The Pill for Males' will never rise to the occasion. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2014/06/140602101704.htm
Federation of American Societies for Experimental Biology. "Why some experimental forms of 'The Pill for Males' will never rise to the occasion." ScienceDaily. www.sciencedaily.com/releases/2014/06/140602101704.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins