Featured Research

from universities, journals, and other organizations

Discovery of compound may open new road to diabetes treatment

Date:
June 4, 2014
Source:
Stony Brook Medicine
Summary:
The discovery of an inhibitor of the Insulin Degrading Enzyme (IDE), a protein responsible for the susceptibility of diabetes because it destroys insulin in the body, may lead to new treatment approaches for diabetes, researchers say. More than 20 million people live with type II diabetes in the United States, a disease in which the body cannot make sufficient amounts of the hormone insulin.

Dr. Markus Seeliger and MD/PhD student Zach Foda determined the 3-D structure of an inhibitor compound and how it is bound to the Insulin Degrading Enzyme (IDE). The inhibitor is depicted in orange and white spheres. The IDE is depicted as the blue and green surface, and the gray ribbons.
Credit: Markus Seeliger, Stony Brook University

The discovery of an inhibitor of the Insulin Degrading Enzyme (IDE), a protein responsible for the susceptibility of diabetes because it destroys insulin in the body, may lead to new treatment approaches for diabetes. In collaboration with the discoverers of the inhibitor, David Liu and Alan Saghatelian, Stony Brook Medicine scientist Markus Seeliger, PhD, and colleagues nationally, demonstrated the efficacy of the compound in a research paper in the early online edition of Nature.

Related Articles


More than 20 million people live with type II diabetes in the United States, a disease in which the body cannot make sufficient amounts of the hormone insulin. IDE removes insulin from the blood. To date, diabetes treatment strategies are based on patients either injecting insulin, taking medicine to make their body more sensitive to insulin, or taking other drugs to stimulate insulin secretion. In the paper, "Anti-diabetic action of insulin-degrading enzyme inhibitors mediated by multiple hormones," the authors reveal results that point to a potential new approach -- regulating the degradation of insulin in the blood.

"A strategy to protect the remaining amounts of insulin produced by diabetics in response to blood sugar levels is an attractive treatment alternative, particularly in the early stages of type II diabetes," said Dr. Seeliger, Assistant Professor in the Department of Pharmacological Sciences at Stony Brook University School of Medicine. "The research results gives proof of concept that targeting this protein is extremely promising. The inhibitor we discovered successfully relieved the symptoms of type II diabetes in obese mice and not only elevated their insulin levels but promoted healthy insulin signaling within the blood."

Using a robotic structural biology facility at Stony Brook and resources at Brookhaven National Laboratory, Dr. Seeliger and Zach Foda, an MD/PhD candidate and student in Dr. Seeliger's laboratory, determined the three-dimensional structure of the inhibitor compound and how it is bound to the IDE. The research team used this 3-D structure to help further evaluate the compound's properties and characteristics.

Dr. Seeliger said that the research findings are important initial steps to developing a drug that diabetics can use to regulate the depletion of insulin in their blood. A realistic initial treatment approach, he added, may be to use the compound to help the body retain insulin levels and thus delay the use of insulin for type II diabetes.


Story Source:

The above story is based on materials provided by Stony Brook Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Juan Pablo Maianti, Amanda McFedries, Zachariah H. Foda, Ralph E. Kleiner, Xiu Quan Du, Malcolm A. Leissring, Wei-Jen Tang, Maureen J. Charron, Markus A. Seeliger, Alan Saghatelian, David R. Liu. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature, 2014; DOI: 10.1038/nature13297

Cite This Page:

Stony Brook Medicine. "Discovery of compound may open new road to diabetes treatment." ScienceDaily. ScienceDaily, 4 June 2014. <www.sciencedaily.com/releases/2014/06/140604133744.htm>.
Stony Brook Medicine. (2014, June 4). Discovery of compound may open new road to diabetes treatment. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2014/06/140604133744.htm
Stony Brook Medicine. "Discovery of compound may open new road to diabetes treatment." ScienceDaily. www.sciencedaily.com/releases/2014/06/140604133744.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins