Featured Research

from universities, journals, and other organizations

First biomarkers found to predict severe osteoarthritis

Date:
June 11, 2014
Source:
European League Against Rheumatism
Summary:
The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2014) identify a correlation between the presence of biomarkers in the blood, known as micro RNAs (miRNAs), and the development of severe osteoarthritis (OA) of the knee or hip joint. The findings suggest that miRNAs may be used as biomarkers to predict severe OA disease in individuals.

The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2014) identify a correlation between the presence of biomarkers in the blood, known as micro RNAs (miRNAs), and the development of severe osteoarthritis (OA) of the knee or hip joint. The findings suggest that miRNAs may be used as biomarkers to predict severe OA disease in individuals.

Related Articles


Preventative measures and early treatments are considered to be the most effective way of managing OA, but to date there has been no way of identifying the disease early on.

"These results indicate that for the first time we will be able to predict the risk of severe osteoarthritis, before the disease starts to significantly impact a person's life, allowing us to take preventative action early on. Through the early identification of osteoarthritis we can decrease both the impact of the disease on individuals and the major socio-economic burden severe disease poses," said Dr Christian Beyer, lead author from University of Erlangen-Nuremberg, Germany.

OA is a common musculoskeletal disorder affecting 10% of the world's population. It is characterised by pain and stiffness in the joints and is one of the top ten most disabling diseases in developed countries, posing a major cause of knee or hip replacements. Disability from the disease has a great impact on individuals, healthcare systems and society, contributing to loss of productivity and inability to work. The average total annual cost of OA per patient is between €1,330 and €10,452 across Europe. With risk factors including advancing age and obesity, the burden of the disease is expected to grow.

This study screened existing serum samples of people with OA, through which they identified three potential miRNA markers. 816 patients were followed over 15 years and measured for the presence of the 374 miRNAs and the occurrence of OA, using joint replacement (known as arthroplasty), as a definitive outcome of severe OA in the knee or hip. Of the 816 patients, 67 patients had one or more total joint replacements for severe knee or hip OA. The results of serum analysis showed a correlation between severe knee or hip OA and three miRNA molecules known as let-7e, miR-454 and miR-885-5p. These results indicate those miRNAs could be used as biomarkers to predict severe OA.

This is the first study to identify differentially expressed miRNAs in osteoarthritis patients necessitating arthroplasty, in a large population-based cohort using the well-defined Bruneck cohort.


Story Source:

The above story is based on materials provided by European League Against Rheumatism. Note: Materials may be edited for content and length.


Cite This Page:

European League Against Rheumatism. "First biomarkers found to predict severe osteoarthritis." ScienceDaily. ScienceDaily, 11 June 2014. <www.sciencedaily.com/releases/2014/06/140611093631.htm>.
European League Against Rheumatism. (2014, June 11). First biomarkers found to predict severe osteoarthritis. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2014/06/140611093631.htm
European League Against Rheumatism. "First biomarkers found to predict severe osteoarthritis." ScienceDaily. www.sciencedaily.com/releases/2014/06/140611093631.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins