Featured Research

from universities, journals, and other organizations

African Americans respond better to first-line diabetes drug than whites

Date:
June 12, 2014
Source:
Endocrine Society
Summary:
African Americans taking the diabetes drug metformin saw greater improvements in their blood sugar control than white individuals who were prescribed the same medication, according to a new study. Metformin is the most common oral medication prescribed for diabetes. It decreases the amount of glucose produced by the liver and helps the body respond better to insulin, the hormone that helps carry sugar from the bloodstream into cells.

African Americans taking the diabetes drug metformin saw greater improvements in their blood sugar control than white individuals who were prescribed the same medication, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

An estimated 29 million Americans have diabetes. African Americans are twice as likely to be diagnosed with diabetes as whites and have a higher rate of complications such as kidney failure, according to the U.S. Department of Health and Human Services' Office of Minority Health.

Metformin is the most common oral medication prescribed for diabetes. It decreases the amount of glucose produced by the liver and helps the body respond better to insulin, the hormone that helps carry sugar from the bloodstream into cells.

"Metformin is normally the first treatment physicians prescribe for type 2 diabetes, but the standard of care is based on clinical trials where the vast majority of participants were white," said one of the study's authors, L. Keoki Williams, MD, MPH, of Henry Ford Health System in Detroit, MI. "We wanted to examine how the drug performed in an African American population. Our findings suggest that African Americans who have diabetes actually respond better to metformin than whites."

The observational study used medical and pharmacy records from Henry Ford Health System to examine blood sugar control in 19,672 people with diabetes who were prescribed metformin between January 1, 1997 and June 2, 2013. Among the participants, 7,429 were African American and 8,783 were white. Using pharmacy records, the researchers estimated each individual's exposure to metformin and other diabetes medications. Each study participant had at least two hemoglobin A1c (HbA1C) blood sugar measurements taken at least four months apart while they were on metformin.

Because the HbA1C test measures a person's average blood sugar level from the past three months, researchers ran an analysis to measure the change in participants' blood sugar levels in relation to the amount of metformin taken.

The study found the maximum dose of metformin was associated with an absolute decrease in HbA1C values of 0.9 percent among African Americans. In contrast, the same analysis found a 0.42 percent reduction in HbA1C numbers among whites.

"When one considers that the goal HbA1c level for individuals being treated for diabetes is less than 7 percent and that the average starting HbA1c level in our patients was around 7.5 percent, these differences in treatment response are clinically important," Williams said. "Moreover, since African Americans are more likely to suffer from diabetic complications when compared with white individuals, it is heartening to observe that metformin is likely more effective at controlling blood glucose in the former group."


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. Keoki Williams, Badri Padhukasahasram, Brian K. Ahmedani, Edward L. Peterson, Karen E. Wells, Esteban Gonzαlez Burchard, David E. Lanfear. Differing Effects of Metformin on Glycemic Control by Race-Ethnicity. The Journal of Clinical Endocrinology & Metabolism, 2014; jc.2014-1539 DOI: 10.1210/jc.2014-1539

Cite This Page:

Endocrine Society. "African Americans respond better to first-line diabetes drug than whites." ScienceDaily. ScienceDaily, 12 June 2014. <www.sciencedaily.com/releases/2014/06/140612132347.htm>.
Endocrine Society. (2014, June 12). African Americans respond better to first-line diabetes drug than whites. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2014/06/140612132347.htm
Endocrine Society. "African Americans respond better to first-line diabetes drug than whites." ScienceDaily. www.sciencedaily.com/releases/2014/06/140612132347.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) — An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) — America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) — The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) — The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins