Featured Research

from universities, journals, and other organizations

African Americans respond better to first-line diabetes drug than whites

Date:
June 12, 2014
Source:
Endocrine Society
Summary:
African Americans taking the diabetes drug metformin saw greater improvements in their blood sugar control than white individuals who were prescribed the same medication, according to a new study. Metformin is the most common oral medication prescribed for diabetes. It decreases the amount of glucose produced by the liver and helps the body respond better to insulin, the hormone that helps carry sugar from the bloodstream into cells.

African Americans taking the diabetes drug metformin saw greater improvements in their blood sugar control than white individuals who were prescribed the same medication, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

An estimated 29 million Americans have diabetes. African Americans are twice as likely to be diagnosed with diabetes as whites and have a higher rate of complications such as kidney failure, according to the U.S. Department of Health and Human Services' Office of Minority Health.

Metformin is the most common oral medication prescribed for diabetes. It decreases the amount of glucose produced by the liver and helps the body respond better to insulin, the hormone that helps carry sugar from the bloodstream into cells.

"Metformin is normally the first treatment physicians prescribe for type 2 diabetes, but the standard of care is based on clinical trials where the vast majority of participants were white," said one of the study's authors, L. Keoki Williams, MD, MPH, of Henry Ford Health System in Detroit, MI. "We wanted to examine how the drug performed in an African American population. Our findings suggest that African Americans who have diabetes actually respond better to metformin than whites."

The observational study used medical and pharmacy records from Henry Ford Health System to examine blood sugar control in 19,672 people with diabetes who were prescribed metformin between January 1, 1997 and June 2, 2013. Among the participants, 7,429 were African American and 8,783 were white. Using pharmacy records, the researchers estimated each individual's exposure to metformin and other diabetes medications. Each study participant had at least two hemoglobin A1c (HbA1C) blood sugar measurements taken at least four months apart while they were on metformin.

Because the HbA1C test measures a person's average blood sugar level from the past three months, researchers ran an analysis to measure the change in participants' blood sugar levels in relation to the amount of metformin taken.

The study found the maximum dose of metformin was associated with an absolute decrease in HbA1C values of 0.9 percent among African Americans. In contrast, the same analysis found a 0.42 percent reduction in HbA1C numbers among whites.

"When one considers that the goal HbA1c level for individuals being treated for diabetes is less than 7 percent and that the average starting HbA1c level in our patients was around 7.5 percent, these differences in treatment response are clinically important," Williams said. "Moreover, since African Americans are more likely to suffer from diabetic complications when compared with white individuals, it is heartening to observe that metformin is likely more effective at controlling blood glucose in the former group."


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. Keoki Williams, Badri Padhukasahasram, Brian K. Ahmedani, Edward L. Peterson, Karen E. Wells, Esteban Gonzαlez Burchard, David E. Lanfear. Differing Effects of Metformin on Glycemic Control by Race-Ethnicity. The Journal of Clinical Endocrinology & Metabolism, 2014; jc.2014-1539 DOI: 10.1210/jc.2014-1539

Cite This Page:

Endocrine Society. "African Americans respond better to first-line diabetes drug than whites." ScienceDaily. ScienceDaily, 12 June 2014. <www.sciencedaily.com/releases/2014/06/140612132347.htm>.
Endocrine Society. (2014, June 12). African Americans respond better to first-line diabetes drug than whites. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2014/06/140612132347.htm
Endocrine Society. "African Americans respond better to first-line diabetes drug than whites." ScienceDaily. www.sciencedaily.com/releases/2014/06/140612132347.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) — A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) — Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) — New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins