Featured Research

from universities, journals, and other organizations

Veterans with blast traumatic brain injury may have unrecognized pituitary dysfunction

Date:
June 23, 2014
Source:
Endocrine Society
Summary:
In soldiers who survive traumatic brain injury from blast exposure, pituitary dysfunction after their blast injury may be an important, under-recognized, and potentially treatable source of their symptoms, a new study finds. "Our study suggests that deficiencies in the pituitary's growth hormone and testosterone are commonly seen after blast traumatic brain injury, especially in patients who are overweight," says an investigator.

In soldiers who survive traumatic brain injury from blast exposure, pituitary dysfunction after their blast injury may be an important, under-recognized, and potentially treatable source of their symptoms, a new study finds. The results were presented in a poster Saturday at ICE/ENDO 2014, the joint meeting of the International Society of Endocrinology and the Endocrine Society in Chicago.

Related Articles


"Our study suggests that deficiencies in the pituitary's growth hormone and testosterone are commonly seen after blast traumatic brain injury, especially in patients who are overweight. Because multiple symptoms common with blast traumatic brain injury are also seen with growth hormone and testosterone deficiencies, perhaps treating these hormone deficiencies will help improve the symptom burden and quality of life for these veterans," said lead study author Jeffrey S. Taylor, MD, endocrinology fellow at Virginia Commonwealth University Medical Center in Richmond, Virginia.

Blast traumatic brain injury (bTBI) is increasingly common in military personnel returning from combat. A common consequence of bTBI in general is pituitary hormone dysfunction, which can occur even without mechanical head trauma and can interfere with the soldier's recovery, long-term health, and overall well-being. A soldier's depression, post-traumatic stress disorder (PTSD), and certain medications may further complicate diagnosing possible pituitary dysfunction, so it often goes unrecognized and untreated.

Expanding on their prior research of the incidence of pituitary dysfunction in male post-bTBI veterans, Dr. Taylor and his colleagues looked at 37 male veterans who had been exposed to combat-related blasts. They evaluated them for bTBI and tested them for hormone dysfunction while screening for and minimizing their use of medications that might interfere with their lab tests.

Of these veterans, 23 had mild and 2 had moderate TBI. Overall, 27% were obese and almost all the men had PTSD. Their exposure to the blast ranged from 2 to 113 months prior to the time their blood samples were taken.

The most common finding involved growth hormone deficiency and hypogonadism associated with low testosterone, especially in their overweight patients, suggesting that these hormone deficiencies occur frequently after bTBI and that treating them may improve their symptoms.

The authors called for further study to address several challenges.

"One challenge in diagnosis is that certain medications commonly used for these patients can interfere with needed laboratory testing. Another is that, although our data suggest that growth hormone deficiency and hypogonadism occur frequently after bTBI, these conditions also appear to be strongly associated with obesity. PTSD and depression may also affect pituitary function. Further study is needed to clarify the extent to which these conditions affect diagnosing true pituitary dysfunction among bTBI survivors and to determine if hormone replacement will benefit them," Dr. Taylor said.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Veterans with blast traumatic brain injury may have unrecognized pituitary dysfunction." ScienceDaily. ScienceDaily, 23 June 2014. <www.sciencedaily.com/releases/2014/06/140623092027.htm>.
Endocrine Society. (2014, June 23). Veterans with blast traumatic brain injury may have unrecognized pituitary dysfunction. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2014/06/140623092027.htm
Endocrine Society. "Veterans with blast traumatic brain injury may have unrecognized pituitary dysfunction." ScienceDaily. www.sciencedaily.com/releases/2014/06/140623092027.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins