Featured Research

from universities, journals, and other organizations

Surgical biopsy proves safe for selected late-stage lung cancer patients

Date:
June 26, 2014
Source:
UC Davis Comprehensive Cancer Center
Summary:
Surgical biopsies can be safely performed on select patients with late-stage non-small cell lung cancer, which should enhance their access to drugs that target specific genetic mutations such as epidermal growth factor receptor (EGFR), researchers report. The findings address a common problem in treatment for advanced lung cancer: insufficient tumor tissue available for molecular analysis, which is required before prescribing targeted therapy.

Dr. David Cooke.
Credit: Image courtesy of UC Davis Comprehensive Cancer Center

Researchers at UC Davis have determined that surgical biopsies can be safely performed on select patients with late-stage non-small cell lung cancer, which should enhance their access to drugs that target specific genetic mutations such as epidermal growth factor receptor (EGFR).

Related Articles


The findings, to be published in the July issue of The Journal of Thoracic and Cardiovascular Surgery, address a common problem in treatment for advanced lung cancer: insufficient tumor tissue available for molecular analysis, which is required before prescribing targeted therapy.

"We will be allowing more people to be eligible for clinical trials, and ultimately that will provide value to the patient and access to treatments they may not have had otherwise," said study lead author David T. Cooke, assistant professor and head of general thoracic surgery at the UC Davis Medical Center.

In many cases of late-stage lung cancer, surgical biopsy is deemed too dangerous, so less invasive approaches are used, including fine needle aspiration and core needle biopsies.

"With clinical trials of new targeted therapies, an exhausting level of testing is performed," Cooke said. "With less invasive biopsies, sometimes the volume of cells collected is insufficient to do the molecular testing."

Cooke and colleagues retrospectively examined the records of 25 patients whose cases were discussed at a multidisciplinary thoracic oncology conference or clinic and who had known or suspected stage IV non-small cell lung cancer. All elected to have surgical biopsies, most of which were done using video-assisted thoracic surgery, a procedure that requires general anesthesia but only small incisions.

Of the cases, five experienced a complication; three of them were minor. Surgical biopsy led to the identification of potentially targetable molecular information in 19 of the 25 patients, and changed the treatment strategy in more than half, with 10 of the 25 also determined eligible for enrollment into a therapeutic targeted clinical trial.

"Patients who have been reviewed in a multidisciplinary manner and for whom less invasive biopsies were not likely to be successful, could be appropriate for surgical biopsy, even at stage IV," Cooke concluded.

Cooke emphasized that the approach should only be used when the case has been reviewed by a team of experts, including a pulmonologist, radiologist, surgeon and medical oncologist, and the best biopsy strategy is selected.

"I think this will change the game," he said. "It will empower thoracic surgeons to work closely with multidisciplinary tumor boards and be participatory in the care of late-stage lung cancer patients."


Story Source:

The above story is based on materials provided by UC Davis Comprehensive Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. David T. Cooke, David R. Gandara, Neal C. Goodwin, Royce F. Calhoun, Primo N. Lara, Philip C. Mack, Elizabeth A. David. Outcomes and efficacy of thoracic surgery biopsy for tumor molecular profiling in patients with advanced lung cancer. The Journal of Thoracic and Cardiovascular Surgery, 2014; DOI: 10.1016/j.jtcvs.2014.03.014

Cite This Page:

UC Davis Comprehensive Cancer Center. "Surgical biopsy proves safe for selected late-stage lung cancer patients." ScienceDaily. ScienceDaily, 26 June 2014. <www.sciencedaily.com/releases/2014/06/140626141019.htm>.
UC Davis Comprehensive Cancer Center. (2014, June 26). Surgical biopsy proves safe for selected late-stage lung cancer patients. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2014/06/140626141019.htm
UC Davis Comprehensive Cancer Center. "Surgical biopsy proves safe for selected late-stage lung cancer patients." ScienceDaily. www.sciencedaily.com/releases/2014/06/140626141019.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins