Featured Research

from universities, journals, and other organizations

Causes of serious pain syndrome closer to discovery

Date:
July 2, 2014
Source:
University of Liverpool
Summary:
A major step forward has been made in understanding the causes of a disorder which causes chronic pain in sufferers. Complex Regional Pain Syndrome (CRPS) is a serious condition affecting a limb after an -- often small -- accident or operation. It can cause severe pain lasting many years, as well as limb swelling, hair and nail growth changes, and muscle atrophy, but until now there has been no clear evidence of the cause.

The study suggests Complex Regional Pain Syndrome could be caused by harmful serum-autoantibodies.
Credit: Image courtesy of University of Liverpool

Researchers at the University of Liverpool have taken a major step forward in understanding the causes of a disorder which causes chronic pain in sufferers.

Related Articles


Complex Regional Pain Syndrome (CRPS) is a serious condition affecting a limb after an -- often small -- accident or operation. It can cause severe pain lasting many years, as well as limb swelling, hair and nail growth changes, and muscle atrophy, but until now there has been no clear evidence of the cause.

Same symptoms

Now the research team from the University's Institute of Translational Medicine alongside colleagues at the University of Pecs, Hungary have successfully transferred antibodies from the serum of patients with CRPS to mice, causing many of the same symptoms to be replicated.

Dr Andreas Goebel, who works in the University of Liverpool and is a Consultant in Pain Medicine at The Walton Centre NHS Foundation Trust, led the study. He said: "CRPS is a serious condition which isn't fully understood.

"The findings of this study hint at a cause for CPRS -- harmful serum-autoantibodies -- and raise the possibility of finding a treatment"

In mice injected with the antibodies from CRPS sufferers, there was significantly more swelling of the affected limbs compared to mice injected with antibodies from healthy volunteers. Similar to what is seen in patient's limbs, the paws of CRPS-antibody injected mice became more painful to pressure, and the paw tissues contained a higher concentration of the nerve-mediator Substance P.

Although it had previously been thought, that the cause of CRPS is exclusively an abnormal brain activity after injury, more recent results, including from the Liverpool group have pointed to an immune dysfunction.

Pinpoint the cause

Dr Goebel said: "It's quite possible that CRPS is caused by a fault in the immune system. This study seems to pinpoint the cause as autoantibodies, and by examining this area further we can look to develop a cure."


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Journal Reference:

  1. Valéria Tékus, Zsófia Hajna, Éva Borbély, Adrienn Markovics, Teréz Bagoly, János Szolcsányi, Victoria Thompson, Ágnes Kemény, Zsuzsanna Helyes, Andreas Goebel. A CRPS-IgG-transfer-trauma model reproducing inflammatory and positive sensory signs associated with complex regional pain syndrome. PAIN®, 2014; 155 (2): 299 DOI: 10.1016/j.pain.2013.10.011

Cite This Page:

University of Liverpool. "Causes of serious pain syndrome closer to discovery." ScienceDaily. ScienceDaily, 2 July 2014. <www.sciencedaily.com/releases/2014/07/140702122531.htm>.
University of Liverpool. (2014, July 2). Causes of serious pain syndrome closer to discovery. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2014/07/140702122531.htm
University of Liverpool. "Causes of serious pain syndrome closer to discovery." ScienceDaily. www.sciencedaily.com/releases/2014/07/140702122531.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins