Featured Research

from universities, journals, and other organizations

Study examines survival following repair of failed bioprosthetic aortic valves

Date:
July 8, 2014
Source:
JAMA - Journal of the American Medical Association
Summary:
In an analysis of about 460 patients with failed bioprosthetic aortic valves who underwent transcatheter valve-in-valve implantation, overall survival at one year was 83 percent, with survival associated with surgical valve size and mechanism of failure, according to a study. Surgical aortic valve replacements increasingly use bioprosthesis implants rather than mechanical valves. Owing to a considerable shift toward bioprosthesis implantation, it is expected that there will be an increase in the number of patients with degeneration of these types of valves.

In an analysis of about 460 patients with failed bioprosthetic aortic valves who underwent transcatheter valve-in-valve implantation, overall survival at one year was 83 percent, with survival associated with surgical valve size and mechanism of failure, according to a study in the July 9 issue of JAMA.

Surgical aortic valve replacements increasingly use bioprosthesis (composed of biological tissue) implants rather than mechanical valves. Owing to a considerable shift toward bioprosthesis implantation, it is expected that there will be an increase in the number of patients with degeneration of these types of valves. Treatment of patients with failed bioprostheses is a clinical challenge; although reoperation is considered the standard of care, these patients are frequently elderly and have other medical conditions, and repeat cardiac surgery can pose significant illness and risk of death. Transcatheter aortic valve-in-valve implantation is a less invasive approach, however a comprehensive evaluation of survival after the procedure has not previously been performed, according to background information in the article.

Danny Dvir, M.D., of St. Paul's Hospital, Vancouver, Canada, and colleagues evaluated survival of 459 patients after transcatheter valve-in-valve implantation inside failed surgical bioprosthetic valves using a multinational registry. The patients (average age, 78 years) underwent implantation between 2007 and May 2013 at 55 centers.

Reasons for bioprosthesis failure were stenosis (narrowing of the valve opening; 39.4 percent), regurgitation (backflow of blood through the orifice of the valve due to imperfect closing; 30.3 percent), and combined stenosis and regurgitation (30.3 percent). The overall 1-year survival rate was 83.2 percent.

Patients in the stenosis group had worse 1-year survival (76.6 percent) in comparison with the regurgitation group (91.2 percent) and the combined group (83.9 percent). Similarly, patients with small valves (≤ 21 mm) had worse 1-year survival (74.8 percent) compared with larger valves.

"Thorough assessment of candidates for valve-in-valve implantation is a key step to obtain optimal results. The current analysis highlights the need for meticulous evaluation of bioprosthesis mechanism of failure before attempting a valve-in-valve procedure," the authors write.


Story Source:

The above story is based on materials provided by JAMA - Journal of the American Medical Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Danny Dvir, John G. Webb, Sabine Bleiziffer, Miralem Pasic, Ron Waksman, Susheel Kodali, Marco Barbanti, Azeem Latib, Ulrich Schaefer, Josep Rodιs-Cabau, Hendrik Treede, Nicolo Piazza, David Hildick-Smith, Dominique Himbert, Thomas Walther, Christian Hengstenberg, Henrik Nissen, Raffi Bekeredjian, Patrizia Presbitero, Enrico Ferrari, Amit Segev, Arend de Weger, Stephan Windecker, Neil E. Moat, Massimo Napodano, Manuel Wilbring, Alfredo G. Cerillo, Stephen Brecker, Didier Tchetche, Thierry Lefθvre, Federico De Marco, Claudia Fiorina, Anna Sonia Petronio, Rui C. Teles, Luca Testa, Jean-Claude Laborde, Martin B. Leon, Ran Kornowski. Transcatheter Aortic Valve Implantation in Failed Bioprosthetic Surgical Valves. JAMA, 2014; 312 (2): 162 DOI: 10.1001/jama.2014.7246

Cite This Page:

JAMA - Journal of the American Medical Association. "Study examines survival following repair of failed bioprosthetic aortic valves." ScienceDaily. ScienceDaily, 8 July 2014. <www.sciencedaily.com/releases/2014/07/140708165725.htm>.
JAMA - Journal of the American Medical Association. (2014, July 8). Study examines survival following repair of failed bioprosthetic aortic valves. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2014/07/140708165725.htm
JAMA - Journal of the American Medical Association. "Study examines survival following repair of failed bioprosthetic aortic valves." ScienceDaily. www.sciencedaily.com/releases/2014/07/140708165725.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) — Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) — State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) — The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) — CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins