Featured Research

from universities, journals, and other organizations

Immune system component found that resists sepsis in mice

Date:
July 9, 2014
Source:
University of Southern California - Health Sciences
Summary:
Mice lacking a specific component of the immune system are completely resistant to sepsis, a potentially fatal complication of infection, molecular microbiologists report. The discovery suggests that blocking this immune system component may help reduce inflammation in human autoimmune and hyper-inflammatory diseases such as rheumatoid arthritis and Type 2 diabetes.

Molecular microbiologists from the Keck School of Medicine of USC have discovered that mice lacking a specific component of the immune system are completely resistant to sepsis, a potentially fatal complication of infection. The discovery suggests that blocking this immune system component may help reduce inflammation in human autoimmune and hyper-inflammatory diseases such as rheumatoid arthritis and Type 2 diabetes.

Related Articles


The study was published online on June 23 in The Journal of Experimental Medicine, a leading peer-reviewed scientific journal in research medicine and immunology.

The immune system is the body's first line of defense against infection. The system, however, can also injure the body if it is not turned off after the infection is destroyed, or if it is turned on when there is no infection at all. Scientists do not yet fully understand how the immune response is turned on and off and continue to study it in hopes of harnessing its power to cure disease.

In this study, scientists have found that a component of the system, HOIL-1L, is necessary for formation of the NLRP3-ASC inflammasome signaling complex.

"This regulatory mechanism is critical in vivo, where we find that mice lacking HOIL-1L are completely resistant to sepsis, which is a lethal inflammation model of human sepsis," said Mary Rodgers, PhD, USC postdoctoral fellow and the study's first author. "Our results suggest that blocking the activity of HOIL-1L could be a new therapeutic strategy for reducing inflammation in disease."


Story Source:

The above story is based on materials provided by University of Southern California - Health Sciences. The original article was written by Alison Trinidad. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. A. Rodgers, J. W. Bowman, H. Fujita, N. Orazio, M. Shi, Q. Liang, R. Amatya, T. J. Kelly, K. Iwai, J. Ting, J. U. Jung. The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation. Journal of Experimental Medicine, 2014; 211 (7): 1333 DOI: 10.1084/jem.20132486

Cite This Page:

University of Southern California - Health Sciences. "Immune system component found that resists sepsis in mice." ScienceDaily. ScienceDaily, 9 July 2014. <www.sciencedaily.com/releases/2014/07/140709095933.htm>.
University of Southern California - Health Sciences. (2014, July 9). Immune system component found that resists sepsis in mice. ScienceDaily. Retrieved March 26, 2015 from www.sciencedaily.com/releases/2014/07/140709095933.htm
University of Southern California - Health Sciences. "Immune system component found that resists sepsis in mice." ScienceDaily. www.sciencedaily.com/releases/2014/07/140709095933.htm (accessed March 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins