Featured Research

from universities, journals, and other organizations

Why weight-loss surgery cures diabetes: New clues

Date:
July 10, 2014
Source:
Manchester University
Summary:
Scientists are a step closer to understanding why diabetes is cured in the majority of patients that undergo gastric bypass surgery."Our research centered on enteroendocrine cells that 'taste' what we eat and in response release a cocktail of hormones that communicate with the pancreas, to control insulin release to the brain, to convey the sense of being full and to optimize and maximize digestion and absorption of nutrients," said the study's team leader.

Scientists at The University of Manchester are a step closer to understanding why diabetes is cured in the majority of patients that undergo gastric bypass surgery.

The research, published in the journal Endocrinology, shows the cure is likely to be explained by the actions of specialized cells in the intestine that secrete a cocktail of powerful hormones when we eat.

During the research, the team showed that gut hormone cells previously thought to contain just one hormone, had up to six hormones including the hunger hormone ghrelin.

Study team leader, Dr Craig Smith, a Senior Lecturer in Molecular Cell Physiology, said: "Our research centred on enteroendocrine cells that 'taste' what we eat and in response release a cocktail of hormones that communicate with the pancreas, to control insulin release to the brain, to convey the sense of being full and to optimize and maximize digestion and absorption of nutrients."

"Under normal circumstances these are all important factors in keeping us healthy and nourished. But these cells may malfunction and result in under or over eating."

75% of people suffering from obesity who also have diabetes are cured of diabetes after receiving a gastric bypass and Dr Smith says that understanding how bypass surgery cures diabetes is the crux of his team's research.

Dr Smith: "This is where things start to get really interesting because the most common type of gastric bypass actually also bypasses a proportion of the gut hormone cells. It is thought that this causes the gut hormone cells to change and be reprogrammed. For us, understanding how these cells change in response to surgery is likely to hold the key to a cure for diabetes."

In the UK, approximately 2.9 million people are affected by diabetes and the most common form of the disease is Type 2 diabetes which is linked to genes, ethnicity, obesity and diet.

"Understanding the messages the gut sends out when we eat food and when things go wrong, as is the case in diabetes, is our next challenge and hopefully one that will result in the development of drugs which could be used instead of surgery to cure obesity and prevent diabetes," said Dr Smith.


Story Source:

The above story is based on materials provided by Manchester University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alexandros G. Sykaras, Claire Demenis, Lei Cheng, Trairak Pisitkun, John T. Mclaughlin, Robert A. Fenton, Craig P. Smith. Duodenal CCK cells from male mice express multiple hormones including ghrelin. Endocrinology, 2014; en.2013-2165 DOI: 10.1210/en.2013-2165

Cite This Page:

Manchester University. "Why weight-loss surgery cures diabetes: New clues." ScienceDaily. ScienceDaily, 10 July 2014. <www.sciencedaily.com/releases/2014/07/140710081302.htm>.
Manchester University. (2014, July 10). Why weight-loss surgery cures diabetes: New clues. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2014/07/140710081302.htm
Manchester University. "Why weight-loss surgery cures diabetes: New clues." ScienceDaily. www.sciencedaily.com/releases/2014/07/140710081302.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins