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Sunscreens do not fully protect against the development of melanoma, mouse study suggests

Date:
July 14, 2014
Source:
Asociación RUVID
Summary:
Sunscreen, even with a sun protection factor (SPF) 50, may not fully protect against the development of melanoma. Sunscreen protects against immediate radiation damage including sunburn, but the radiation can still penetrate and damage the DNA of cells and cause cancer, according to an animal study.

Berta López Sánchez-Laorden.
Credit: Image courtesy of Asociación RUVID

The researcher at the Neurosciences Institute, Joint Center of the University Miguel Hernández (UMH) in Elche and the Higher Council for Scientific Research (CSIC), Berta López Sánchez-Laorden co-authored a study that concluded that sunscreens do not protect totally against the development of skin cancer. The research was recently published in Nature.

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The study demonstrates that sunscreen, even with a sun protection factor (SPF) 50, may not fully protect against the development of melanoma. According to the researcher at the UMH Berta López Sánchez-Laorden, sunscreen protects against immediate radiation damage including sunburn, but the radiation can still penetrate and damage the DNA of cells and cause cancer.

Through the use of genetically modified mice particularly susceptible to melanoma, the researcher discovered that ultraviolet light causes mutations in the DNA of melanocytes in a gene called p53. This is one of the genes considered as guardians of the genome as it is key in detecting and repairing damage that accumulates in cells, such as the produced by ultraviolet light, and is a major barrier of the body against cancer.

Several epidemiological studies have shown an association between sun exposure and the increased risk of melanoma. However, the molecular mechanism that causes this to happen was not clear.

Berta López Sánchez-Laorden is co-author of the work, which has been one of the main projects carried out during her first postdoctoral, developed in the Institute of Cancer Research in London and the Cancer Research UK Manchester Institute.


Story Source:

The above story is based on materials provided by Asociación RUVID. Note: Materials may be edited for content and length.


Journal Reference:

  1. Amaya Viros, Berta Sanchez-Laorden, Malin Pedersen, Simon J. Furney, Joel Rae, Kate Hogan, Sarah Ejiama, Maria Romina Girotti, Martin Cook, Nathalie Dhomen, Richard Marais. Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53. Nature, 2014; DOI: 10.1038/nature13298

Cite This Page:

Asociación RUVID. "Sunscreens do not fully protect against the development of melanoma, mouse study suggests." ScienceDaily. ScienceDaily, 14 July 2014. <www.sciencedaily.com/releases/2014/07/140714100342.htm>.
Asociación RUVID. (2014, July 14). Sunscreens do not fully protect against the development of melanoma, mouse study suggests. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2014/07/140714100342.htm
Asociación RUVID. "Sunscreens do not fully protect against the development of melanoma, mouse study suggests." ScienceDaily. www.sciencedaily.com/releases/2014/07/140714100342.htm (accessed March 2, 2015).

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