Featured Research

from universities, journals, and other organizations

New hope for treatment of Alzheimer's disease: Role of genetic variant may delay onset

Date:
July 15, 2014
Source:
Douglas Mental Health University Institute
Summary:
A relatively frequent genetic variant actually conveys significant protection against the common form of Alzheimer's disease and can delay the onset of the disease by as much as 4 years, new research has shown.

Judes Poirier, PhD, C.Q., from the Douglas Mental Health Institute and McGill University in Montrιal (Canada) and his team have discovered that a relatively frequent genetic variant actually conveys significant protection against the common form of Alzheimer's disease and can delay the onset of the disease by as much as 4 years. This discovery opens new avenues for treatment against this devastating disease.

Dr. Poirier announced his findings as the annual Alzheimer's Association International Conference was taking place in Copenhagen. This large-scale study identified naturally occurring genetic variants that provide protection against the common form of Alzheimer's disease, with the goal of identifying specific biological processes amenable to pharmaceutical interventions.

"We found that specific genetic variants in a gene called HMG CoA reductase which normally regulates cholesterol production and mobilization in the brain can interfere with, and delay the onset of Alzheimer's disease by nearly 4 years. This is an exciting breakthrough in a field where successes have been scarce these past few years" says Dr. Poirier, whose previous research led to the discovery that a genetic variant was formally associated with the common form of Alzheimer's disease.

"These latest genetic results from Dr. Poirier's team are an important step forward in the understanding of Alzheimer's disease neurobiology, and also the use of genetics to identify an interesting new molecular target that is amenable to therapeutic development" added Brigitte Kieffer, Scientific Director of the Research Centre of the Douglas Mental Health University Institute."

A different approach

Over the past two decades, research efforts around the globe have focused on identifying genetic and environmental factors responsible for causing or accelerating the progression of the common form of Alzheimer's disease. However, little was known about possible protective genetic factors that can delay or even prevent the disease onset in humans. It is well documented that a subset of older individuals who happen to be carriers of predisposing genetic factors for the common form of Alzheimer's manage to escape the disease and live long and productive lives without any memory problems until their 90's.


Story Source:

The above story is based on materials provided by Douglas Mental Health University Institute. Note: Materials may be edited for content and length.


Cite This Page:

Douglas Mental Health University Institute. "New hope for treatment of Alzheimer's disease: Role of genetic variant may delay onset." ScienceDaily. ScienceDaily, 15 July 2014. <www.sciencedaily.com/releases/2014/07/140715092833.htm>.
Douglas Mental Health University Institute. (2014, July 15). New hope for treatment of Alzheimer's disease: Role of genetic variant may delay onset. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2014/07/140715092833.htm
Douglas Mental Health University Institute. "New hope for treatment of Alzheimer's disease: Role of genetic variant may delay onset." ScienceDaily. www.sciencedaily.com/releases/2014/07/140715092833.htm (accessed September 3, 2014).

Share This



More Health & Medicine News

Wednesday, September 3, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) — You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) — As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) — When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins