Featured Research

from universities, journals, and other organizations

Cholesterol drug cuts heart, stroke risks by 30 percent in diabetic women: Study

Date:
August 18, 2014
Source:
University of Sydney
Summary:
The cholesterol-lowering drug fenofibrate cuts cardiovascular disease risks by 30 percent in women with type 2 diabetes, a new study reveals. The leading cause of death in women, cardiovascular disease (CVD) is a constellation of ailments affecting the heart and blood vessels, including conditions such as coronary heart disease, stroke, and diseases of the small blood vessels, such as in the eyes and kidneys.

The cholesterol-lowering drug fenofibrate cuts cardiovascular disease risks by 30 per cent in women with type-2 diabetes, a new University of Sydney study reveals.

Related Articles


"The finding is good news for women," says the study's chairman, University of Sydney Professor, Tony Keech.

"The study shows that fenofibrate reduced the risk of dying from cardiovascular disease, or having a stroke or other adverse cardiovascular event by 30 per cent in women and 13 per cent in men."

The leading cause of death in women, cardiovascular disease (CVD) is a constellation of ailments affecting the heart and blood vessels, including conditions such as coronary heart disease, stroke, and diseases of the small blood vessels, such as in the eyes and kidneys.

Published in Diabetologia, the five-year study of nearly 10,000 people with type-2 diabetes also assessed fenofibrate's impact on a range of lipoproteins and triglycerides (circulating blood fats) that elevate the risk of cardiovascular events such as stroke and heart attack, and the need for medical procedures such as coronary artery bypass graft surgery.

Among type-2 diabetic patients with an elevated risk of cardiovascular disease -- those with high levels of triglycerides and low levels of "good" cholesterol (high-density lipoprotein or HDL) -- fenofibrate cut adverse cardiovascular outcomes by 30 per cent in women and 24 per cent in men.

A previous smaller US study had suggested that fenofibrate was not beneficial for women. This new study recommends that fenofibrate be considered as a useful way to reduce the risk of cardiovascular disease in both women and men with Type-2 diabetes.

High cholesterol is a serious health problem affecting one in three Australians. It is a leading risk factor for the deposition of circulating fats on the walls of blood vessels (atherosclerosis), which heightens the risk of heart attack and stroke.

Fenofibrate stimulates the action of an enzyme that breaks down triglycerides and low-density lipoproteins. Stimulating this enzyme increases the breakdown of triglycerides (another type of blood lipid) and low-density lipoproteins in the bloodstream and raises HDL cholesterol.

"Cardiovascular disease is the most common cause of death in women, almost three times more common than breast cancer," says the study's lead author, Associate Professor Michael d'Emden of the Royal Brisbane Hospital.

"Its symptoms are sometimes harder to diagnose in women and often the typical chest pain of a heart attack does not occur in people with diabetes.

"Therefore, better awareness among patients and their GPs is vital. Predominant symptoms include breathlessness, sweating, nausea, fatigue or arm pain."

Fast facts

  • Cardiovascular disease is a major cause of death among women
  • Cardiovascular disease affects one in six Australians (3.7 million people)
  • Women who have a heart attack are more likely than men to die from it
  • Women are more likely than men to have a second cardiovascular event, such as a stroke or heart attack

Story Source:

The above story is based on materials provided by University of Sydney. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tony Keech et al. Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Diabetologia, August 2014 DOI: 10.1007/s00125-014-3344-3

Cite This Page:

University of Sydney. "Cholesterol drug cuts heart, stroke risks by 30 percent in diabetic women: Study." ScienceDaily. ScienceDaily, 18 August 2014. <www.sciencedaily.com/releases/2014/08/140818192637.htm>.
University of Sydney. (2014, August 18). Cholesterol drug cuts heart, stroke risks by 30 percent in diabetic women: Study. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2014/08/140818192637.htm
University of Sydney. "Cholesterol drug cuts heart, stroke risks by 30 percent in diabetic women: Study." ScienceDaily. www.sciencedaily.com/releases/2014/08/140818192637.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins