Featured Research

from universities, journals, and other organizations

Native American ancestry a risk factor for eye disease

Date:
August 21, 2014
Source:
University of Southern California - Health Sciences
Summary:
Native American ancestry is a significant risk factor for vision-threatening diabetic retinopathy among Latinos with type 2 diabetes, a new study shows for the first time. Using genetic assays and detailed ophthalmologic examinations, the team found that individuals with more than 50 percent Native American ancestry had an 87 percent higher chance of also having vision-threatening diabetic retinopathy compared to those who had less than 50 percent Native American ancestry, even after controlling for known risk factors for the disease.

New research led by the University of Southern California (USC) Eye Institute, part of Keck Medicine of USC, shows for the first time that Native American ancestry is a significant risk factor for vision-threatening diabetic retinopathy among Latinos with Type 2 diabetes. Diabetic retinopathy is the leading cause of blindness in working-age adults in the United States, affecting more than 4 million Americans age 40 and older.

The research was published online in Investigative Ophthalmology & Visual Science, the peer-reviewed academic journal of The Association for Research in Vision and Ophthalmology.

Diabetic retinopathy occurs when blood vessels in the eye's retina are damaged. The retina is the light-sensitive tissue at the back of the eye that acts like a film inside a camera; like damaged film, a damaged retina will produce a bad picture. Symptoms may not be noticeable at first, but the disease can get worse over time and lead to vision loss.

"This is the first study, to our knowledge, that examines the contribution of genetic ancestry in vision-threatening diabetic eye disease in Latinos," said USC Eye Institute Director Rohit Varma, M.D., M.P.H., professor and chair of the Department of Ophthalmology at the Keck School of Medicine of USC and the study's principal investigator. "Previous research has shown that Latinos have a higher prevalence of diabetic retinopathy than non-Hispanic Whites and African-Americans. Our findings suggest that one contributor to this heavy burden may be due to their Native American ancestry."

Latinos are a diverse group of people typically with a varying mixture of Native American, European and African ancestry. Varma's research team examined data from 944 Latinos with Type 2 diabetes from the Los Angeles Latino Eye Study (LALES), the largest population-based study of eye disease in that ethnic group. The participants in the study were 40 years of age or older and hailed from the city of La Puente in Los Angeles County, California. Ninety-five percent of them were of Mexican origin. Of the 944 people with type II diabetes, 135 had vision-threatening diabetic retinopathy while 809 did not.

Using genetic assays and detailed ophthalmologic examinations, the team found that individuals with more than 50 percent Native American ancestry had an 87 percent higher chance of also having vision-threatening diabetic retinopathy compared to those who had less than 50 percent Native American ancestry, even after controlling for known risk factors for the disease.

"Our next steps will be to try to narrow down which genomic locations among those with a Native American origin might be contributing to boosting the risk for developing severe diabetic retinopathy," said Xiaoyi Gao, the study's first author who started his research at USC. Gao is now associate professor of ophthalmology in the University of Illinois, Chicago College of Medicine.


Story Source:

The above story is based on materials provided by University of Southern California - Health Sciences. The original article was written by Alison Trinidad. Note: Materials may be edited for content and length.


Journal Reference:

  1. X. Gao, W. J. Gauderman, P. Marjoram, M. Torres, Y.-D. I. Chen, K. D. Taylor, J. I. Rotter, R. Varma. Native American ancestry is associated with severe diabetic retinopathy in Latinos. Investigative Ophthalmology & Visual Science, 2014; DOI: 10.1167/iovs.14-15044

Cite This Page:

University of Southern California - Health Sciences. "Native American ancestry a risk factor for eye disease." ScienceDaily. ScienceDaily, 21 August 2014. <www.sciencedaily.com/releases/2014/08/140821132653.htm>.
University of Southern California - Health Sciences. (2014, August 21). Native American ancestry a risk factor for eye disease. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2014/08/140821132653.htm
University of Southern California - Health Sciences. "Native American ancestry a risk factor for eye disease." ScienceDaily. www.sciencedaily.com/releases/2014/08/140821132653.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins