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Increased risk of stroke in people with cognitive impairment

Date:
August 25, 2014
Source:
Canadian Medical Association Journal
Summary:
People with cognitive impairment are significantly more likely to have a stroke, with a 39 percent increased risk, than people with normal cognitive function, according to a new study. Cognitive impairment and stroke are major contributors to disability, and stroke is the second leading cause of death world-wide. Although stroke is linked to the development and worsening of cognitive impairment, it is not known whether the reverse is true.

People with cognitive impairment are significantly more likely to have a stroke, with a 39% increased risk, than people with normal cognitive function, according to a new study published in CMAJ (Canadian Medical Association Journal).

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"Given the projected substantial rise in the number of older people around the world, prevalence rates of cognitive impairment and stroke are expected to soar over the next several decades, especially in high-income countries," writes Dr. Bruce Ovbiagele, Chair of the Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, with coauthors.

Cognitive impairment and stroke are major contributors to disability, and stroke is the second leading cause of death world-wide. Although stroke is linked to the development and worsening of cognitive impairment, it is not known whether the reverse is true. Previous studies that have looked at the link between cognitive impairment and subsequent stroke have been inconsistent in their findings.

The study in CMAJ, by researchers in the United States, Taiwan and South Korea, analyzed data from 18 studies of 121 879 people with cognitive impairment, of whom 7799 later had strokes. Most of the included studies were conducted in North America or Europe.

The researchers observed a significantly higher rate of stroke in people with cognitive impairment than in people with normal cognitive function.

"We found that the risk of future stroke was 39% higher among patients with cognitive impairment at baseline than among those with normal cognitive function at baseline," write the authors. "This risk increased to 64% when a broadly adopted definition of cognitive impairment was used."

Blockage of blood vessels in the brain (brain infarcts), atherosclerosis, inflammation and other vascular conditions are associated with a higher risk of stroke and cognitive impairment and may contribute to the increased risk.

"Cognitive impairment should be more broadly recognized as a possible early clinical manifestation of cerebral infarction, so that timely management of vascular risk factors can be instituted to potentially prevent future stroke events and to avoid further deterioration of cognitive health," conclude the authors.


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Meng Lee, Jeffrey L. Saver, Keun-Sik Hong, Yi-Ling Wu, Hsing-Cheng Liu, Neal M. Rao, and Bruce Ovbiagele. Cognitive impairment and risk of future stroke: a systematic review and meta-analysis. CMAJ, August 2014 DOI: 10.1503/cmaj.140147

Cite This Page:

Canadian Medical Association Journal. "Increased risk of stroke in people with cognitive impairment." ScienceDaily. ScienceDaily, 25 August 2014. <www.sciencedaily.com/releases/2014/08/140825130148.htm>.
Canadian Medical Association Journal. (2014, August 25). Increased risk of stroke in people with cognitive impairment. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2014/08/140825130148.htm
Canadian Medical Association Journal. "Increased risk of stroke in people with cognitive impairment." ScienceDaily. www.sciencedaily.com/releases/2014/08/140825130148.htm (accessed October 26, 2014).

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