Featured Research

from universities, journals, and other organizations

Over-the-counter pain reliever may restore immune function in old age

Date:
September 2, 2014
Source:
Federation of American Societies for Experimental Biology
Summary:
New research involving mice suggests that the key to more youthful immune function might already be in your medicine cabinet. Scientists have shown that macrophages from the lungs of old mice had different responses to Mycobacterium tuberculosis than macrophages from young mice, but these changes were reversed by ibuprofen.

New research published in the Journal of Leukocyte Biology suggests that macrophages from the lungs of old mice responded differently to infections than those of young mice, ibuprofen reversed these changes.

New research involving mice suggests that the key to more youthful immune function might already be in your medicine cabinet. In a report published in the Journal of Leukocyte Biology scientists show that macrophages from the lungs of old mice had different responses to Mycobacterium tuberculosis than macrophages from young mice, but these changes were reversed by ibuprofen.

"Inflammation in old age can have significant consequences on immune function," said Joanne Turner, Ph.D., a researcher involved in the work from the Department of Microbial Infection and Immunity and Center for Microbial Interface Biology at The Ohio State University in Columbus, Ohio. "With this knowledge, it may be possible to reduce or prevent some diseases in the elderly by decreasing inflammation with diet, exercise and/or drugs."

To make this discovery, scientists measured inflammatory markers in the total lung or within purified macrophage populations of young healthy mice and of old healthy mice. Inflammatory markers were elevated in old mice, and isolated macrophages from both old and young healthy mice responded differentially to infection with Mycobacterium tuberculosis in vitro. This suggests that the altered interactions with M. tuberculosis were linked to inflammation in old age. The researchers then placed a group of old, but healthy, mice on an ibuprofen supplemented diet, and this reduced inflammation and restored immune function to that of young healthy mice.

"This may give new meaning to the phrase 'take two aspirins and call me in the morning,'" said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "The report may not be about aspirin, but it does show that over-the-counter remedies may broader value that usually appreciated, including by affecting immune functions that change with age."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. H. Canan, N. S. Gokhale, B. Carruthers, W. P. Lafuse, L. S. Schlesinger, J. B. Torrelles, J. Turner. Characterization of lung inflammation and its impact on macrophage function in aging. Journal of Leukocyte Biology, 2014; 96 (3): 473 DOI: 10.1189/jlb.4A0214-093RR

Cite This Page:

Federation of American Societies for Experimental Biology. "Over-the-counter pain reliever may restore immune function in old age." ScienceDaily. ScienceDaily, 2 September 2014. <www.sciencedaily.com/releases/2014/09/140902114715.htm>.
Federation of American Societies for Experimental Biology. (2014, September 2). Over-the-counter pain reliever may restore immune function in old age. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2014/09/140902114715.htm
Federation of American Societies for Experimental Biology. "Over-the-counter pain reliever may restore immune function in old age." ScienceDaily. www.sciencedaily.com/releases/2014/09/140902114715.htm (accessed October 20, 2014).

Share This



More Plants & Animals News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
White Rhino's Death In Kenya Means Just 6 Are Left

White Rhino's Death In Kenya Means Just 6 Are Left

Newsy (Oct. 20, 2014) Suni, a rare northern white rhino at Ol Pejeta Conservancy, died Friday. This, as many media have pointed out, leaves people fearing extinction. Video provided by Newsy
Powered by NewsLook.com
Fish Fossil Shows First-Ever Sex Was Done Side By Side

Fish Fossil Shows First-Ever Sex Was Done Side By Side

Newsy (Oct. 19, 2014) A 380-million-year-old fish may be the first creature to have copulative sex - and it was side by side with arms linked, like square dancers. Video provided by Newsy
Powered by NewsLook.com
Study Links Soda To Accelerated DNA Aging

Study Links Soda To Accelerated DNA Aging

Newsy (Oct. 19, 2014) Researchers at the University of California San Francisco found the sugar in soda might accelerate the body's aging process. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins