Researchers working on new tuberculosis vaccine
- Date:
- October 13, 2015
- Source:
- Tulane University
- Summary:
- Researchers are currently developing a new vaccine for tuberculosis, one of the world's deadliest diseases. Using a modified strain of TB, they show that monkeys could generate better protective immunity than when vaccinated with BCG, a common TB vaccine.
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Researchers at the Tulane National Primate Research Center (TNPRC) are leading efforts to find a new vaccine for tuberculosis, one of the world's deadliest diseases. Tuberculosis, a contagious infection of the lungs, affected more than nine million people in 2013, killing more than one million.
A team of researchers led by the TNPRC used a modified strain of TB to show that monkeys could generate better protective immunity than when vaccinated with BCG, a common TB vaccine.
In their experiments the Tulane researchers used Mycobacterium tuberculosis (Mtb) -- a strain modified to lose a stress response gene called SigmaH. Monkeys that received aerosols of the modified strain resisted infection with Mtb better than the similarly-delivered BCG, and showed glimpses of protective immune response in their lungs.
"While the results are exciting, we believe further work is needed before this excitement can be translated to human trials," says Deepak Kaushal, PhD, Professor at TNPRC. "More monkey studies are needed to validate these results in alternative settings, and more modifications may be necessary to add to the strain we're working with in order to safeguard it further. However, the impact of the current work in identifying what is needed to protect against TB, and, in a model that closely mimics human infection, is unquestionable."
Grants from the National Institutes of Health are supporting this study. More information can be found in the journal Nature Communications.
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Materials provided by Tulane University. Note: Content may be edited for style and length.
Journal Reference:
- Deepak Kaushal, Taylor W. Foreman, Uma S. Gautam, Xavier Alvarez, Toidi Adekambi, Javier Rangel-Moreno, Nadia A. Golden, Ann-Marie F. Johnson, Bonnie L. Phillips, Muhammad H. Ahsan, Kasi E. Russell-Lodrigue, Lara A. Doyle, Chad J. Roy, Peter J. Didier, James L. Blanchard, Jyothi Rengarajan, Andrew A. Lackner, Shabaana A. Khader, Smriti Mehra. Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis. Nature Communications, 2015; 6: 8533 DOI: 10.1038/ncomms9533
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