New! Sign up for our free email newsletter.
Science News
from research organizations

Study identifies a signaling cascade behind retina regeneration in zebrafish

The findings could help inform treatments for blindness in humans

Date:
December 20, 2022
Source:
Michigan Medicine - University of Michigan
Summary:
Experts are investigating how cells called Muller glial cells, responsible for regenerating a damaged zebrafish retina, acquire stem cell properties with the hope of eventually developing techniques to encourage human retinas to regenerate.
Share:
FULL STORY

Blinding eye diseases like macular degeneration, diabetic retinopathy, and glaucoma are accompanied by the death of neurons in the retina that leads to blindness.

Although several strategies are being investigated for restoring sight to the people who are blind, including using stem cells from the body to regenerate retinal neurons lost to injury or disease. While regenerative stem cells have not been identified in the adult human retina, they have been found in zebrafish.

Experts at U-M Medical School are investigating how cells called Muller glial cells, responsible for regenerating a damaged zebrafish retina, acquire stem cell properties with the hope of eventually developing techniques to encourage human retinas to regenerate.

Building on their work that identified the cells, a new study reported in Proceedings of the National Academy of Science, led by postdoctoral fellow Sumitra Mitra, Ph.D., and research lab specialist Sulochana Devi, Ph.D., in the lab of Daniel Goldman, Ph.D., investigates whether cells other than dying neurons influence Muller glia's regenerative response.

Interestingly, these cells are present in both the zebrafish and human retina, and in both species, they contribute to retinal structure and homeostasis; however, only in zebrafish do these cells respond to retinal neurodegeneration by adopting stem cell properties that allow them to regenerate retinal neurons.

With the new study, they discovered a Vegf-Notch signaling system that is activated in the injured retina and connects Muller glia with immune cells and cells lining blood vessels. Importantly, they found that each of these cell types contributes to the gene expression changes necessary for Muller glial cell reprogramming and acquisition of stem cell properties.

Interestingly, this signaling system is not found in mammals and thus, might help explain why the human retina does not regenerate.

This work was funded by the Gilbert Family Foundation Vision Restoration Initiative and the NEI.


Story Source:

Materials provided by Michigan Medicine - University of Michigan. Original written by Kelly Malcom. Note: Content may be edited for style and length.


Journal Reference:

  1. Soumitra Mitra, Sulochana Devi, Mi-Sun Lee, Jonathan Jui, Aresh Sahu, Daniel Goldman. Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences, 2022; 119 (50) DOI: 10.1073/pnas.2211690119

Cite This Page:

Michigan Medicine - University of Michigan. "Study identifies a signaling cascade behind retina regeneration in zebrafish." ScienceDaily. ScienceDaily, 20 December 2022. <www.sciencedaily.com/releases/2022/12/221220112953.htm>.
Michigan Medicine - University of Michigan. (2022, December 20). Study identifies a signaling cascade behind retina regeneration in zebrafish. ScienceDaily. Retrieved October 31, 2024 from www.sciencedaily.com/releases/2022/12/221220112953.htm
Michigan Medicine - University of Michigan. "Study identifies a signaling cascade behind retina regeneration in zebrafish." ScienceDaily. www.sciencedaily.com/releases/2022/12/221220112953.htm (accessed October 31, 2024).

Explore More

from ScienceDaily

RELATED STORIES