Science News
from research organizations

Modelling the effect of vaccines on cholera transmission

Date:
August 4, 2015
Source:
World Scientific
Summary:
Cholera is a diarrheal disease that is caused by an intestinal bacterium, Vibrio cholerae. Recently an outbreak of cholera in Haiti brought public attention to this deadly disease. In this work, the goal of our differential equation model is to find an effective optimal vaccination strategy to minimize the disease related mortality and to reduce the associated costs.
Share:
FULL STORY

Cholera is a diarrheal disease that is caused by an intestinal bacterium, Vibrio cholerae. Recently an outbreak of cholera in Haiti brought public attention to this deadly disease. In this work, the goal of our differential equation model is to find an effective optimal vaccination strategy to minimize the disease related mortality and to reduce the associated costs. The effect of seasonality in pathogen transmission on vaccination strategies was investigated under several types of disease scenarios, including an endemic case and a new outbreak case. This model is an extension of a general water-borne pathogen model. This work involves the optimal control problem formulation, analysis and numerical simulations.

What optimal vaccination strategies should be used during a cholera outbreak? The effect of seasonality in pathogen transmission on vaccination strategies was investigated under several types of disease scenarios, including an endemic case and a new outbreak case. The model is an extension of a general water-borne pathogen model. This work involves optimal control problem formulation, analysis and numerical simulations.


Story Source:

Materials provided by World Scientific. Note: Content may be edited for style and length.


Journal Reference:

  1. URMI GHOSH-DASTIDAR, SUZANNE LENHART. MODELING THE EFFECT OF VACCINES ON CHOLERA TRANSMISSION. Journal of Biological Systems, 2015; 23 (02): 323 DOI: 10.1142/S0218339015500175

Cite This Page:

World Scientific. "Modelling the effect of vaccines on cholera transmission." ScienceDaily. ScienceDaily, 4 August 2015. <www.sciencedaily.com/releases/2015/08/150804100108.htm>.
World Scientific. (2015, August 4). Modelling the effect of vaccines on cholera transmission. ScienceDaily. Retrieved May 23, 2017 from www.sciencedaily.com/releases/2015/08/150804100108.htm
World Scientific. "Modelling the effect of vaccines on cholera transmission." ScienceDaily. www.sciencedaily.com/releases/2015/08/150804100108.htm (accessed May 23, 2017).

RELATED STORIES